Publications by authors named "A G Togias"
Background: Determining why some upper respiratory illnesses provoke asthma exacerbations remains an unmet need.
Objective: To identify transcriptome-wide gene expression changes associated with colds that progress to exacerbation.
Methods: 208 urban children (6-17 years) with exacerbation-prone asthma were prospectively monitored for up to two cold illnesses.
Background: Rhinoconjunctivitis phenotypes are conventionally described on the basis of symptom severity, duration and seasonality, and aeroallergen sensitization. It is not known whether these phenotypes fully reflect the patterns of symptoms seen at a population level.
Objective: We sought to identify phenotypes of rhinoconjunctivitis on the basis of symptom intensity and seasonality using an unbiased approach and to compare their characteristics.
Objective: Understanding compliance with COVID-19 mitigation recommendations is critical for informing efforts to contain future infectious disease outbreaks. This study tested the hypothesis that higher levels of worry about COVID-19 illness among household caregivers would predict lower (a) levels of overall and discretionary social exposure activities and (b) rates of household SARS-CoV-2 infections.
Methods: Data were drawn from a surveillance study of households with children ( = 1913) recruited from 12 U.
Article Synopsis
- - Food Protein-Induced Enterocolitis (FPIES) is a type of food allergy that occurs primarily in children and is characterized by symptoms such as delayed vomiting, lethargy, and pale skin, typically emerging 1-4 hours after consuming the allergen.
- - Despite increasing recognition of FPIES, its exact causes remain unknown, and there are no specific tests to diagnose or track the condition's progress.
- - A recent workshop by the National Institute of Allergy and Infectious Diseases (NIAID) focused on FPIES, discussing current understanding, research gaps, and future priorities for improving diagnosis and management.
Article Synopsis
- Chronic rhinitis in children is linked to significant health issues and varies widely in symptoms, highlighting the need to define specific phenotypes for better treatment.
- The study tracked 485 urban children from ages 1 to 11 to identify patterns of rhinitis and their connections to early life factors, other allergies, and nasal cell gene expression.
- Four rhinitis phenotypes were found: low/minimal, persistent, persistent decreasing, and late increasing, with persistent symptoms associated with increased allergic sensitization and specific risk factors like frequent colds and antibiotic use.