[Expression of epidermal growth factor receptor and concentrations of epidermal growth factor and melatonin in endometrial carcinoma].

The aim of the research was to study the Epidermal Growth Factor Receptor (EGFR) expression, measure Epidermal Growth Factor (EGF) and melatonin concentrations in patients with endometrial carcinomas. In order to reveal EGFR expression, immunohistochemical examination of morphologic material (tumor of the uterine body, histopathological diagnosis: endometrial carcinoma) from 21 patients was performed. The EGF blood plasma levels were measured using the method of high performance liquid chromatography (HPLC).

[Epidermal growth factor receptor expression and epidermal growth factor blood plasma content in simple and complex endometrial hyperplasia].

The goal of our study was to concurrently determine the prognostic significance of Epidermal Growth Factor Receptor (EGFR) expression in endometrium and Epidermal Growth Factor (EGF) blood content in simple and complex hyperplasia. In order to detect EGFR expression, immunohistochemical examination of endometrial scarp from 35 patients was done along with HPLC (High performance liquid chromatography) method, for measuring EGF blood plasma content. The numerical data obtained were processed statistically using computer program SPSS-12.

[Expression of epidermal growth factor receptor and plasmatic level of melatonin in simple and complex endometrial hyperplasia].

The goal of our research was to find the prognostic significance of the epidermal growth factor receptor (EGFR) in the hyperplastic endometrium. Immunohistochemical study of morphological material (endometrial scrap) was conducted in order to reveal the EGFR expression (in 35 patients). The study of consistence of melatonin (universal antiproliferative and anticancerogenic hormone) in patients' blood serum was performed as well (using ELISA method).

Pancreatic D-cells in aging and intraislet effects of pancreatic somatostatin.

In old organisms pancreatic D-cells are not changed in number. During the aging in mentioned cells takes place the intensification of secretory and extrusive functions, which are more prominent in old organisms than in young ones. Peripherally situated D-cells are vascularly ineffective within the pancreatic islet and do not suppress locally B- and A-cells.

The study of melatonin protective activity on pancreatic β-cells under the condition of alloxan-induced diabetes during aging.

The aim of our research was to study the influence of melatonin on pancreatic β-cells under the condition of alloxan-induced Diabetes Mellitus - especially in old age, when the mentioned disease frequently takes place. 56 male white rats were used in the study. Two age groups were selected: adult period of life and late senescent period of life.