Prodomain processing controls BMP-10 bioactivity and targeting to fibrillin-1 in latent conformation.

Bone morphogenetic protein 10 (BMP-10) is crucial for endothelial cell signaling via activin receptor-like kinase 1 (ALK1), a pathway central to vascular homeostasis and angiogenesis. Dysregulated BMP-10 signaling contributes to cardiovascular diseases and cancer, highlighting the need to control ALK1-mediated endothelial responses to BMP-10 for therapeutic development. BMP-10 biosynthesis involves processing by proprotein convertases (PPCs) resulting in a non-covalently associated prodomain-growth factor (PD-GF) complex (CPLX), similar to other TGF-β superfamily ligands.

Accelerating materials property prediction via a hybrid Transformer Graph framework that leverages four body interactions.

Machine learning has advanced the rapid prediction of inorganic materials properties, yet data scarcity for specific properties and capturing thermodynamic stability remains challenging. We propose a framework utilizing a Graph Neural Network with composition-based and crystal structure-based architectures, combined with a transfer learning scheme. This approach accurately predicts energy-related properties (e.

[Efficacy and safety of Aviandr in the treatment of anxiety in patients with adjustment disorders after COVID-19].

Objective: To investigate the efficacy and safety of Aviandr in the treatment of anxiety in patients with adjustment disorders after COVID-19.

Material And Methods: A multicenter prospective open-label study included 109 patients of both sexes aged 18 to 65 years (70 women, 39 men, average age - 41.4±13.