Publications by authors named "A G Taghian"
Purpose: Randomized trials have demonstrated similar local tumor control in patients treated with accelerated partial-breast irradiation (APBI) compared with whole-breast irradiation. However, the optimal APBI dose for maximizing tumor control and minimizing toxicity is uncertain.
Methods And Materials: We enrolled patients ≥18 years of age with grade 1 or 2 ductal carcinoma in situ or stage I invasive breast cancer and resection margins ≥2 mm between 2003 and 2011 to a sequential dose-escalation trial using 3-dimensional conformal external beam APBI giving twice daily 4 Gy fractions with total doses of 32 Gy, 36 Gy, and 40 Gy.
Article Synopsis
- The study examines complications related to immediate breast reconstruction after mastectomy in patients with and without postmastectomy radiotherapy (PMRT), comparing pre-pectoral and subpectoral implant placements.
- Out of 3,039 patients reviewed between 2005 and 2020, 815 met the criteria for analysis, with a follow-up of 6.2 years, showing no significant differences in major complications between the two implant placements.
- The results indicated that while there was no notable difference in infection or reconstruction failures between proton and photon therapies, patients undergoing proton therapy had a higher risk of capsular contracture and overall reconstruction failure.
Importance: Postmastectomy radiation therapy (PMRT) improves local-regional disease control and patient survival. Hypofractionation (HF) regimens have comparable efficacy and complication rates with improved quality of life compared with conventional fractionation (CF) schedules. However, the use of HF after mastectomy in patients undergoing breast reconstruction has not been prospectively examined.
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