Publications by authors named "A G Sychev"

Background: Hemorrhagic stroke (HS) is associated with high risk of mortality or disability. To date, up to 25% of HSs are associated with anticoagulants and antiplatelet agents. Early hemostatic therapy and correction of effect of antithrombotic drugs in patients with HS significantly reduce the risk of adverse outcomes.

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Recent studies of the spread of substances penetrating the disrupted blood-brain barrier have revealed that the spread in the parenchyma surrounding a vessel has a complex character. In particular, a flow-like motion occurred for a short time that exhibits a smooth transition to diffusional spread. To address the possible physical background of such behavior, we created a system formed by a hydrogel medium with a channel filled by a marker solution, which can serve as a physical model mimicking the process of a substance passively spreading to the brain's parenchyma when the blood-brain barrier is disrupted.

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For the first time, we introduced chemomechanical self-oscillating poly(N-isopropylacrylamide)-based gels containing catalytically active Fe or Ru complexes both as crosslinkers and as pendant groups. All the obtained gels exhibited sustained autonomous oscillations driven by the Belousov-Zhabotinsky reaction within their structure. The Ru complex-based gels also demonstrated pronounced chemomechanical oscillations; they periodically swelled/shrunk when the catalyst was reduced/oxidized.

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Article Synopsis
  • The study presents a model for bacterial population growth influenced by stochastic variations in population size and controlled duplication.
  • The model can simulate different growth patterns, including logistic, hindered, and linear growth based on selected control functions.
  • The findings are validated by comparing the model's predictions with actual growth data from M. tuberculosis populations monitored under various synchronization conditions.
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