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View Article and Find Full Text PDFZh Vopr Neirokhir Im N N Burdenko
December 2024
Background: Hemorrhagic stroke (HS) is associated with high risk of mortality or disability. To date, up to 25% of HSs are associated with anticoagulants and antiplatelet agents. Early hemostatic therapy and correction of effect of antithrombotic drugs in patients with HS significantly reduce the risk of adverse outcomes.
View Article and Find Full Text PDFRecent studies of the spread of substances penetrating the disrupted blood-brain barrier have revealed that the spread in the parenchyma surrounding a vessel has a complex character. In particular, a flow-like motion occurred for a short time that exhibits a smooth transition to diffusional spread. To address the possible physical background of such behavior, we created a system formed by a hydrogel medium with a channel filled by a marker solution, which can serve as a physical model mimicking the process of a substance passively spreading to the brain's parenchyma when the blood-brain barrier is disrupted.
View Article and Find Full Text PDFFor the first time, we introduced chemomechanical self-oscillating poly(N-isopropylacrylamide)-based gels containing catalytically active Fe or Ru complexes both as crosslinkers and as pendant groups. All the obtained gels exhibited sustained autonomous oscillations driven by the Belousov-Zhabotinsky reaction within their structure. The Ru complex-based gels also demonstrated pronounced chemomechanical oscillations; they periodically swelled/shrunk when the catalyst was reduced/oxidized.
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