Accurate isoform discovery with IsoQuant using long reads.

Annotating newly sequenced genomes and determining alternative isoforms from long-read RNA data are complex and incompletely solved problems. Here we present IsoQuant-a computational tool using intron graphs that accurately reconstructs transcripts both with and without reference genome annotation. For novel transcript discovery, IsoQuant reduces the false-positive rate fivefold and 2.

Local ancestry prediction with .

Summary: We developed , a new tool for determining local ancestry along a genome using whole-genome sequencing data or high-density genotyping experiments. PyLAE can process an arbitrarily large number of ancestral populations (with or without an informative prior). Since does not involve estimating many parameters, it can process thousands of genomes within a day.

[Objective evaluation of the caries prevention efficiency].

Background: The aim of the study was to test caries preventive gel compositions by a developed and patented objective laboratory method for evaluating the effectiveness of prophylactic agents based on the active transport of ions through tooth enamel.

Material And Methods: The experiment used a prototype device for assessing ion transport and pork fangs filled with saline solution and immersed in various caries preventive media. An electric current was passed through the device and then the internal solution was analyzed in laboratory conditions for the concentration of ions in it.

[Magnetic resonance imaging in the diagnosis of tuberculous arthritis].

A complex of clinical radiation and MRI studies of the joint was conducted in 45 patients with tuberculous arthritis. Two major forms of tuberculous lesion of the joint were identified: primary osseous tuberculous arthritis (79.6%) and tuberculous allergic synovitis (20.