Publications by authors named "A G Segre"
Importance: Primary open-angle glaucoma (POAG) is a heritable disease. A polygenic risk score (PRS) threshold may be used to identify individuals at low risk of disease onset.
Objective: To assess the utility of a POAG PRS to identify ocular hypertensive individuals at low risk of disease onset.
Article Synopsis
- - The ANGPT-TEK pathway is crucial for forming the Schlemm canal, and mutations in related genes are linked to congenital glaucoma in kids, while a specific SNP (rs76020419) offers protection against open-angle glaucoma in studies.
- - Researchers created mutant mice with the SNP using CRISPR/Cas9 and measured ANGPT2 levels and Schlemm canal size in various tissues.
- - Results showed that mutant mice had higher ANGPT2 levels and a larger Schlemm canal compared to wild-type mice, indicating a possible protective benefit against glaucoma related to this genetic variant.
Purpose: We used a polygenic risk score (PRS) to identify high-risk groups for primary open-angle glaucoma (POAG) within population-based cohorts.
Design: Secondary analysis of 4 prospective population-based studies.
Participants: We included four European-ancestry cohorts: the United States-based Nurses' Health Study, Nurses' Health Study 2, and the Health Professionals Follow-up Study and the Rotterdam Study (RS) in The Netherlands.
Hospitalizations among family members increase the risk of MRSA infection in a household.
Infect Control Hosp Epidemiol
July 2024
Objective: Estimate the risk for household transmission of Methicillin-Resistant Staphylococcus aureus (MRSA) following exposure to infected family members or family members recently discharged from a hospital.
Design: Analysis of monthly MRSA incidence from longitudinal insurance claims using the Merative MarketScan Commercial and Medicare (2001-2021) databases.
Setting: Visits to inpatient, emergency department, and outpatient settings.
Purpose: To investigate the causal effect of elevated blood pressure on primary open-angle glaucoma (POAG) and POAG endophenotypes.
Methods: Two-sample Mendelian randomization (MR) was performed to investigate the causal effect of elevated systolic blood pressure (SBP) (N = 757,601) and diastolic blood pressure (DBP) (N = 757,601) on intraocular pressure (IOP) (N = 139,555), macular retinal nerve fiber layer (mRNFL) thickness (N = 33,129), ganglion cell complex (GCC) thickness (N = 33,129), vertical cup-to-disc ratio (VCDR) (N = 111,724), and POAG liability (Ncases = 16,677, Ncontrols = 199,580). The primary analysis was conducted using the inverse-variance weighted approach.