[Correction of lipoprotein lipid peroxidation in experimental atherosclerosis with polyunsaturated fatty acids combined with antioxidants].

Atherosclerotic lesion of the aorta and lipid peroxidation (LPO) in blood and in lipoproteins produced in hepatocytes were studied in rabbits with experimental atherosclerosis maintained on a diet enriched in polyunsaturated fatty acids containing in corn oil (2 ml/kg daily during 30 days) and antioxidants alpha-tocopherol and carnosine (2.5 mg/kg and 50 mg/kg, respectively, daily during 30 days). This diet exhibited a hypocholesterolemic effect accompanied by approximately a 10-fold decrease of the impaired aortic area, as well as lowered content of 2-thiobarbituric acid-positive LPO products occurring in blood and, especially, in apoB lipoproteins.

[Antiatherogenic action of corn oil in experimental atherosclerosis].

Therapeutic effect of corn oil was studied in rabbits with alimentary atherosclerosis. Corn oil was administered (2 ml/kg, 30 days) after the completion of cholesterol diet unlike studies, where they were administered simultaneously. Total cholesterol, apoB-lipoprotein cholesterol and triglycerides decreased more intensively in rabbits fed by corn oil than in control group.

[Rabbit liver secretes oxidated lipoproteins in experimental atherosclerosis].

It is shown in rabbits, that alimentary hypercholesterolemia proceeds with increasing lipid peroxidation in liver homogenate, blood serum and apo-B-containing lipoproteins. It is established in the model of liver perfusion in rabbits, that liver cells produce apo-B-containing level of lipid peroxidation. The lipid peroxidation increases in perfusate and in the fraction of lipoproteins (d less than 1,065 g/cm3) from this perfusate.