Biomarkers.

Background: This study examines an exceptional case of CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy), a hereditary cerebrovascular disease caused by a mutation in the notch3 gene. In contrast to typical cases manifesting before the age of 50 with migraines, this report highlights an atypical presentation in a 70-year-old woman with no history of migraines nor cognitive impairment.

Method: The patient, with a history of type 2 diabetes, hypothyroidism, and dyslipidemia, was initially treated for cognitive impairment and behavioral changes under suspicion of autoimmune encephalitis.

Biomarkers.

Background: Objective sleep measures obtained from actigraphy (wrist-worn accelerometry) reveal sleep disruption patterns and may serve as indicators of neurodegenerative disease. However, whether individuals' subjective account of their sleep quality corresponds to objective sleep measurements from the previous night is an area little studied. In particular, whether neurodegenerative disease modifies these associations is unknown.

Public Health.

Background: It is increasingly clear that delaying the onset of Alzheimer's disease (AD) dementia by several years can meaningfully lower its prevalence. The goal of the present study is to examine the relationship between lifestyle activities and cognition function as well as cerebrospinal fluid (CSF) biomarkers of AD to determine whether these activities can serve as protective factors for AD resistance and resilience.

Methods: 173 cognitively normal older individuals (mean ± SD, 69 ± 6.

Developing Topics.

Background: α-Synuclein is the hallmark pathology of Parkinson's disease and dementia with Lewy bodies, described together as Lewy body disease (LBD). α-Synuclein is also commonly observed in the context of Alzheimer's disease (AD). Here we investigate the frequency of α-synuclein positivity in an AD research cohort and clinically unimpaired individuals (CU), as well as associations with demographics and AD biomarkers.

Elucidation of Antimicrobials and Biofilm Inhibitors Derived from a Polyacetylene Core.

The development of new antibiotics with unique mechanisms of action is paramount to combating the growing threat of antibiotic resistance. Recently, based on inspiration from natural products, an asymmetrical polyacetylene core structure was examined for its bioactivity and found to have differential specificity for different bacterial species based on the substituents around the conjugated alkyne. This research further probes the structural requirements for bioactivity through a systematic synthesis and investigation of new compounds with variable carbon chain length, alkynyl subunits, and alcohol substitution.