Publications by authors named "A G Robledo"
Cerebrospinal fluid (CSF) leaks commonly occur due to trauma or surgical procedures. Here we review CSF leak diagnosis and management in Low- and Middle-Income Countries (LMICs). A systematic review of the CSF leak management in LMICs was conducted using PubMed, Google Scholar, Embase and Web of Science databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
View Article and Find Full Text PDFMinimally invasive neural interfaces can be used to diagnose, manage and treat many disorders, with reduced risks of surgical complications. However, endovascular probes lack access to key cortical, subcortical and spinal targets, and are not typically explantable after endothelialization. Here we report the development and testing, in sheep, of endocisternal neural interfaces that approach brain and spinal cord targets through inner and outer spaces filled with cerebrospinal fluid.
View Article and Find Full Text PDFNeurotrauma registries (NTR) collect data on traumatic brain injuries (TBI) to advance knowledge, shape policies, and improve outcomes. This study reviews global NTRs from High-Income (HICs) and Low- and Middle-Income countries (LMICs). A systematic review was conducted using PubMed, Google Scholar, Embase, and Web of Science following PRISMA guidelines to identify relevant NTRs.
View Article and Find Full Text PDFIntroduction: In children and adolescents, brain and central nervous system (CNS) tumors are the leading types of cancers. Past studies have found differing rates of intracranial cancers among races and identified additional cancer risk factors. This study aimed to see if these differences can be substantiated with further investigation of the latest version (2019) of the Kids' Inpatient Database (KID).
View Article and Find Full Text PDFArticle Synopsis
- Brain arteriovenous malformations (bAVMs) are risky blood vessel abnormalities in the brain caused by mutations, particularly in the KRAS gene.
- Research using mice models shows that these mutations lead to bAVMs in specific locations of the brain that match patterns found in humans, and these locations are tied to the likelihood of bleeding events.
- Blocking a specific pathway linked to KRAS mutations may offer a non-surgical treatment option for managing bAVMs, suggesting promising therapeutic approaches for affected patients.