[A role of genetic factors and related disorder of the folate cycle in ischemic stroke].

Aim: To study a role of MTHFR mutations and their associations with the disturbances of basic parameters of the folate cycle in the development of ischemic stroke (IS).

Material And Methods: Fifty-one post-stroke patients, 26 women and 25 men, aged from 29 to 87 years, were included in the study. The control group consisted of 47 healthy people, 23 women and 24 men, aged from 30 to 83 years.

[Prognostic criteria of rehabilitation of patients with ischemic stroke].

Aim: To identify prognostic criteria of the restoration of movement in patients after acute disturbance of cerebral blood circulation.

Material And Methods: Results of clinical examination of 82 patients after the acute disturbance of blood circulation in the left hemisphere were analyzed in the Center for Speech Pathology and Neurorehabilitation. The degree of hemiparesis was compared with disease history data, results of electroencephalography, ultrasound and transcranial dopplerography, computed tomography and biochemical study.

[Development of main disturbances of hemostasis in patients with obesity].

According to current views obesity especially with increased amount of visceral fat is characterized by prothrombogenic changes of hemostasis and fibrinolysis. This combined with insulin resistance, compensatory hyperinsulinemia, disturbances of carbohydrate metabolism, atherogenic dyslipidemia and hypertension substantially increases risk of origination and progression of cardiovascular diseases. Results of our study demonstrate high prevalence of various prothrombogenic abnormalities in coagulation and anticoagulation systems in patients with visceral obesity and metabolic syndrome (MS).

Progressive toxemia with acetaldehyde in a reactive form of alcohol withdrawal syndrome.

We carried out a complex clinical and laboratory examination of 169 patients with reactive form of alcohol withdrawal syndrome. Progressive toxemia with acetaldehyde (key pathogenetic stage) and volemic changes were followed by homeostasis disorders and gradual decompensation of the natural detoxification system. The patients with this form of alcohol withdrawal syndrome did not exhibit physical and psychic dependence on alcohol.