Publications by authors named "A G Pershina"
Article Synopsis
- Antibiotic resistance, particularly with beta-lactam antibiotics, poses a significant health threat, highlighting the need for quick and accurate detection methods to improve patient care and combat resistance spread.
- This study presents a novel approach using surface-enhanced Raman spectroscopy (SERS) combined with machine learning (ML) to effectively identify genetic markers associated with antibiotic resistance in bacterial plasmids.
- The SERS-ML technique demonstrated effective detection of resistant plasmids even in challenging biological samples, offering a simpler and faster alternative to current monitoring methods for antibiotic-resistant bacteria.
Article Synopsis
- - A new strategy for preventing cancer metastasis involves using a combination of three specific microRNAs (miR-195-5p, miR-520a, and miR-630) that help stop cancer cells from reverting to a stem cell-like state, which is linked to their ability to spread.
- - Researchers conducted transcriptome microarray analysis to observe how these microRNAs affected gene expression in human breast cancer cell lines, finding that the microRNA mixture reduced the cells' ability to form mammosphere clusters in lab conditions.
- - When the microRNAs were delivered in lipid nanoparticles, they effectively prevented lung metastasis in a mouse model, suggesting this combination could lead to promising new treatments that thwart the growth of secondary tumors.
The presence of anti-polyethylene glycol (PEG) antibodies can limit the clinical efficacy of PEGylated drugs and cause anaphylactic reactions in patients. Monocytes/macrophages are effector cells involved in IgG-mediated passive systemic anaphylaxis. We studied the influence of human blood serum on the efficiency of uptake of PEGylated nanoparticles by human blood monocytes.
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- Testing various derivatives of a specific compound demonstrated significant cytotoxic activity against several cancer cell lines, especially for types like 4T1 and HepG2.
- The research revealed that the effective compounds must include both a difluorobenzoxazine fragment and a purine residue connected by a specific length linker.
- Further studies indicated that the most promising compound inhibits DNA biosynthesis, suggesting potential for developing new antitumor agents based on the identified purine conjugates.
Article Synopsis
- The surface architecture of nanoparticles, influenced by ligand modifications and protein interactions in biofluids, is essential for their cellular interactions in living organisms.
- In this study, we examined how immune cells interact with magnetic nanoparticles modified with polyethylene glycol (PEG) and peptide ligands, discovering that pHLIP modification improved their uptake by immune cells compared to cycloRGD.
- Although we didn't find notable differences in protein corona composition between the modified and unmodified nanoparticles, variations in nanoparticle uptake were observed among different individuals, highlighting the need to consider personal differences in serum during nanotherapy testing.