SSN2: The next generation of spatial stream network modeling in R.

The SSN2 package provides tools for spatial statistical modeling, parameter estimation, and prediction on stream (river) networks. SSN2 is the successor to the SSN package (Ver Hoef, Peterson, Clifford, & Shah, 2014), which was archived alongside broader changes in the -spatial ecosystem (Nowosad, 2023) that included 1) the retirement of rgdal (Bivand, Keitt, & Rowlingson, 2021), rgeos (Bivand & Rundel, 2020), and maptools (Bivand & Lewin-Koh, 2021) and 2) the lack of active development of sp (Bivand, Pebesma, & Gómez-Rubio, 2013). SSN2 maintains compatibility with the input data file structures used by the SSN package but leverages modern -spatial tools like sf (Pebesma, 2018).

Factors influencing autumn-winter movements of midcontinent Mallards and consequences for harvest and habitat management.

Annual phenology and distributions of migratory wildlife have been noticeably influenced by climate change, leading to concerns about sustainable populations. Recent studies exploring conditions influencing autumn migration departure have provided conflicting insights regarding factors influencing the movements of Mallards (), a popular game species. We determined factors affecting timing and magnitude of long-distance movements of 97 juvenile Mallards during autumn-winter across the midcontinent of North America marked with implanted transmitters in North and South Dakota, 2018-2019.

Targeting a KRAS i-motif forming sequence by unmodified and gamma-modified peptide nucleic acid oligomers.

Growing interest in i-motif DNA as a transcriptional regulatory element motivates development of synthetic molecules capable of targeting these structures. In this study, we designed unmodified peptide nucleic acid (PNA) and gamma-modified PNA (γPNA) oligomers complementary to an i-motif forming sequence derived from the promoter of the KRAS oncogene. Biophysical techniques such as circular dichroism (CD) spectroscopy, CD melting, and fluorescence spectroscopy demonstrated the successful invasion of the i-motif by PNA and γPNA.

Online behavioural activation during the COVID-19 pandemic decreases depression and negative affective bias.

Background: The COVID-19 pandemic highlighted the need for mental health interventions that can be easily disseminated during a crisis. Behavioural activation (BA) is a cost-effective treatment that can be administered by non-specialists; however, it is unclear whether it is still effective during a time of lockdown and social distancing, when opportunities for positive activity are significantly constrained.

Methods: Between May and October 2020, we randomised 68 UK participants with mild to moderate low mood to either a 4-week online programme of non-specialist administered BA or to a passive control group.

Impact of an Orthopedic-Delivered 'One-Stop' Clinic for Ambulatory Trauma on Emergency Department and Fracture Clinic Pressures During the COVID-19 Pandemic.

Introduction:  In March 2020, the World Health Organization declared the severe acute respiratory syndrome (SARS) (coronavirus disease, COVID-19) outbreak as a pandemic. In response to the rising number of coronavirus cases in the United Kingdom, the British Orthopaedic Association (BOA) issued a series of emergency guidelines for the management of trauma and orthopedic patients during the pandemic. In line with this guidance, the orthopedic team at the Worcestershire Royal Hospital set up a 'one-stop-shop' minor injuries unit (MIU).