[Effect of the preparation "Loshtak" on the clastogenic activity cyclophosphamide].

The anticlastogenic effect of the herbal preparation Loshtak on rats and mice was tested using the same scheme of treatment and doses of the preparation as are employed in medical practice. It was shown that intragastric administration of Loshtak results in a statistically significant decrease in the clastogenic effect of cyclophosphamide injected 48 h after the end of treatment with Loshtak. High doses of Loshtak did not induce any increase in the number of micronuclei in mouse bone marrow cells.

[Level of monohydroxyeicosatetraenoic acid in the blood of patients with cerebral blood circulation disorders].

Content of 5-, 8-, 11-, 12- and 15-monohydroxyeicosatetraenoic acids was markedly increased in blood of patients with cerebral atherosclerosis accompanied by discirculatory encephalopathy and brain infarction. These values were lower in the patients with infarction as compared with healthy people. After tourniquet ischemia of limbs concentration of the eicosatetraenoic acids was altered in blood of patients: in one group the concentration of all the lipoxygenase metabolites of arachidonic acid was increased, in the other group of patients it was decreased.

[Level of leukotrienes B4 and C4 in the blood of patients with periodic disease].

The level of LTB4 and LTC4 in blood plasma of patients with familial mediterranean fever is significantly higher than in healthy donors: 53 + 10 pg/ml for LTB4 (normal - 25 + 5 pg/ml) and 175 + 22 pg/ml for LTC4 (normal 67 + 19 pg/ml). The more increase of the LTB4 and LTC4 content in plasma is observed during attacks of fever - 107 + 21 pg/ml (LTB4) and 249 + 34 pg/ml (LTC4). Hyperbaric oxygenation of patients, used to relieve pain and fever, reduces the level of leukotrienes.

[The level of leukotrienes B4 and C4 in the blood serum of rats subjected to thermal burns, x-irradiation and combined radiation-thermal injuries].

In the present study the content of leukotrienes B4 and C4 (LTB and LTC) in rat serum was investigated. The changes in the leukotriene content after thermal burn was different from that after X-irradiation and combined effect of radiation and heat.