Publications by authors named "A G Palini"
Article Synopsis
- Developed a new ICP-MS method for analyzing 20 elements in 10 μL of serum and 12 elements in under 250,000 cells, making it reliable and easy to use.
- Conducted proof-of-concept studies that revealed noticeable differences in elemental profiles between serum and immune T cells from naı̈ve versus tumor-bearing mice.
- This research opens up new possibilities for studying rare cell populations and small biofluid samples, providing insights into the role of elements in biological and disease processes.
Background And Aims: Brain white matter hyperintensities (WMHs) have been associated with an increased risk of ischemic stroke and considered as markers of brain ischemia. Progression of WMHs in asymptomatic patients with non-hemodynamically significant carotid plaque could represent a putative marker of plaque vulnerability. We prospectively evaluate progression and determinants of WMHs in this population.
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- Researchers have developed a method to efficiently produce pancreatic progenitors from human induced pluripotent stem cells (hiPSCs), which can lead to improved cell therapies for type 1 diabetes.
- These hiPSC-derived pancreatic endoderm cells (HiPECs) can mature into glucose-responsive islet-like cells when encapsulated and implanted in vivo.
- The HiPECs demonstrated the ability to protect mice from diabetes-related hyperglycemia and maintain normal blood glucose levels, showcasing their potential for clinical use in treating type 1 diabetes.
Research on age-related regenerative failure of skeletal muscle has extensively focused on the phenotypes of muscle stem cells (MuSCs). In contrast, the impact of aging on regulatory cells in the MuSC niche remains largely unexplored. Here, we demonstrate that aging impairs the function of mouse fibro-adipogenic progenitors (FAPs) and thereby indirectly affects the myogenic potential of MuSCs.
View Article and Find Full Text PDFBackground: We explored the relation between blood concentrations of monocyte/lymphocyte subsets and carotid artery plaque macrophage content, measured by positron emission tomography (PET) with C-PK11195.
Methods And Results: In 9 patients with carotid plaques we performed C-PK11195-PET/computed tomography angiography imaging and measurement of absolute concentrations and frequencies of circulating monocytes and T-cell subsets. Plaque standardized uptake value (SUV) for C-PK11195 was negatively correlated with concentrations of total monocytes (r = -0.