Publications by authors named "A G Palestine"
Introduction: Combined uveitis-rheumatology clinics (combined clinics) are a relatively recent clinical care model. Here we report the demographics, ocular and systemic disease characteristics, and medications utilized in patients seen in a combined clinic at a tertiary care hospital in the USA.
Methods: Medical records were reviewed of patients seen at the Combined Clinic at the University of Colorado Hospital between January 1, 2016 and November 1, 2023.
Treatment of Ocular Surface Disease in Ocular Cicatricial Pemphigoid.
Ocul Immunol Inflamm
December 2024
Article Synopsis
- This study investigates the management of ocular surface disease (OSD) related to ocular cicatricial pemphigoid (OCP) at the University of Colorado Hospital, focusing on treatment effectiveness and patient outcomes.
- A total of 30 patients with OCP were evaluated, revealing that common treatments included preservative-free artificial tears, topical corticosteroids, and autologous serum eye drops, with most patients requiring multiple therapies.
- The findings suggest that as OCP severity increases, the need for more intensive OSD management also rises, emphasizing the importance of tailored treatments for advanced cases.
Article Synopsis
- Cytomegalovirus (CMV) chronic retinal necrosis (CRN) is a rare infection that affects mildly immunocompromised individuals and is treated with ganciclovir, but resistance can develop.
- An 80-year-old woman with rheumatoid arthritis experienced blurry vision and was diagnosed with retinitis caused by CMV, initially treated with ganciclovir, but later switched to foscarnet and other medications due to resistance.
- The case highlights the potential increase in CMV CRN cases due to rising use of mild immunosuppressive therapies, and suggests that using combinations like letermovir and leflunomide may be effective alternatives when resistance occurs.
Article Synopsis
- - The study evaluated the use of a 0.18-mg fluocinolone acetonide implant to treat pediatric noninfectious uveitis in patients under 18 years old from June 2020 to March 2023.
- - Out of 11 eyes from seven patients examined, an 82% rate of remaining recurrence-free was observed at 6 months, but this dropped to 60% at both 12 and 24 months, indicating some challenges in long-term efficacy.
- - While the implant showed similar effectiveness in treating pediatric uveitis compared to adults, it was associated with a higher rate of ocular hypertension, leading to the need for surgical intervention in some cases.
Association Between Systemic Levels of Vascular Endothelial Growth Factor and Optical Coherence Tomography Biomarkers in a Non-Neovascular Age-Related Macular Degeneration Cohort.
Ophthalmic Surg Lasers Imaging Retina
January 2025
Background And Objective: Investigate associations between systemic vascular endothelial growth factor (VEGF) and optical coherence tomography (OCT) biomarkers in eyes with complete retinal pigment epithelium and outer retina atrophy (cRORA) secondary to non-neovascular age-related macular degeneration.
Patients And Methods: Cross-sectional study of patients with cRORA. OCT images and blood samples were collected at study enrollment.