Publications by authors named "A G Orr"
Article Synopsis
- In May 2017, whole-genome sequencing became the main method for identifying bacterial strains in Canada, leading to the discovery of 16 multi-jurisdictional outbreaks linked to frozen raw breaded chicken products between 2017 and 2019.
- Of the 487 reported cases, there were 79 hospitalizations and 2 deaths, mainly involving individuals with a median age of 24 years, with the majority of outbreaks linked to a specific bacterial strain.
- Following ineffective prior measures, new regulations were introduced in 2019 to enforce manufacturing practices aimed at reducing bacteria levels, and since their implementation, no further outbreaks related to these products have occurred in Canada.
Introduction: Pediatric patients with complex cardiac diagnoses are at increased risk for physical, cognitive, and developmental complications. Formalized school support [i.e.
View Article and Find Full Text PDFAtherosclerotic cardiovascular disease (ASCVD), the leading cause of mortality worldwide, is driven by endothelial cell inflammatory activation and counter-balanced by anti-inflammatory transcription factors Klf2 and Klf4 (Klf2/4). Understanding vascular endothelial inflammation to develop effective treatments is thus essential. Here, we identify, Polycomb Repressive Complex (PRC) 2, which blocks gene transcription by trimethylating histone3 Lysine27 in gene promoter/enhancers, as a potent, therapeutically targetable determinant of vascular inflammation and ASCVD progression.
View Article and Find Full Text PDFThe immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell-mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown to significantly contribute to Alzheimer's disease (AD) pathology, the nature and extent of immune responses in the brain in the context of AD and related dementias (ADRD) remain unclear. Furthermore, the roles of the peripheral immune system in driving ADRD pathology remain incompletely elucidated.
View Article and Find Full Text PDFArticle Synopsis
- The literature review focuses on identifying larvae of the Calopterygoidea group in the Oriental Realm, aiming to help researchers classify them accurately despite scattered information.
- It offers a comprehensive key for families and some generas, highlighting areas where knowledge is lacking regarding larvae identification.
- Of the 50 genera in the region, larvae for 28 are known, but many still lack clear morphological traits for confident identification, especially in the Chlorocyphidae family.