Publications by authors named "A G Moses"
Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults, characterized by resistance to conventional therapies and poor survival. Ferroptosis, a form of regulated cell death driven by lipid peroxidation, has recently emerged as a promising therapeutic target for GBM treatment. However, there are currently no non-invasive imaging techniques to monitor the engagement of pro-ferroptotic compounds with their respective targets, or to monitor the efficacy of ferroptosis-based therapies.
View Article and Find Full Text PDFBackground: Wound healing is a complex biological process involving numerous cellular and molecular events. and flowers have been traditionally used for their medicinal properties, prompting an investigation into their combined effects on wound healing using both and in silico approaches.
Methods: and flowers were processed in a 1:1 ratio using an ethanolic solvent.
Background The Centers for Medicare & Medicaid Services (CMS) introduced changes in outpatient and inpatient evaluation and management (E/M) current procedural terminology (CPT) codes in 2021 and 2023, which were intended to streamline providers' clinical documentation. Objectives To study the effects of aligning inpatient and outpatient note templates with updated CMS guidelines on character length and documentation time per note at an internal medicine residency program in the southeastern United States. Methods In April 2023, the Atrium Health Wake Forest Baptist Internal Medicine Residency Program's inpatient and outpatient note templates were updated according to the most recent CMS guidelines.
View Article and Find Full Text PDFArticle Synopsis
- Metastatic progression in cancers worsens survival rates and complicates treatment, prompting the development of an mRNA therapy aimed at inhibiting metastasis by targeting activin A, a key factor in metastasis and cachexia.
- This therapy uses follistatin mRNA lipid nanoparticles to effectively reduce activin A levels, resulting in lowered tumor burden and less metastatic spread in a mouse model of head and neck cancer.
- Treated mice showed less metastatic occurrence, preserved muscle and fat tissue, and a good safety profile, suggesting the therapy could be widely applicable across different cancers due to the common overexpression of activin A.
Background: Substance use and abuse of psychoactive substances, alcohol, and illicit drugs, result in dependence, crimes, illicit financial flows, corruption, and terrorism/insurgency.
Objectives: To evaluate the risk factors, prevalence, and patterns of substance abuse, among adult patients attending the Behavioural Medical Unit, Karu General Hospital, Abuja; for prevention and early clinical diagnosis.
Method: A hospital-based descriptive cross-sectional study conducted, from March 2022 to May 2022; involving 257 consenting adults, 18 years and above, selected through systematic random sampling.