Four-Centre, Multi-Electron Bonding in Rare-Earth Germole Sandwich Complexes.

Reduction of the germole-ligated sandwich complexes [(η5-CpGe)M(η5-Cpttt)]2 (1M, M = Y, Gd, Dy) with one or two equivalents of KC8/2.2.2-cryptand produces [(η5-CpGe)M(η5-Cpttt)2]- (2M) and [(η5-CpGe)M(η5-Cpttt)2]2- (3M), respectively, as salts of [K(2.

Nationwide insights into frailty: Systematic review and meta-analysis of community-based prevalence studies from India.

Frailty, a biologic syndrome of decreased reserve and resistance to stressors, affects 5 % to 17 % of older adults and is linked to factors like low BMI, female sex, and low exercise levels. With India's older population expected to double by 2050, frailty presents major public health and economic challenges. This study summarizes the prevalence of frailty among community-dwelling Indians.

Why Antiholins? Thermodynamic and Kinetic Arguments to Explain the Robustness of Bacteriophage Cell Lysis.

Cell lysis is one of the most common biological processes in which viruses infect and destroy bacterial cells. It is accomplished by viruses stimulating cell hosts to produce holin proteins that assemble in cellular membranes and break them at specific times. One of the most surprising observations in cell lysis is that antiholin proteins that inhibit membrane permeabilization are also produced.

Multifunctional slippery nanoemulsion-infused porous nitric oxide-releasing surfaces.

The need for biocompatible materials for medical devices remains critical, as complications such as infection, thrombosis, and biofouling significantly contribute to medical device failure and patient morbidity and mortality. In recent years, nitric oxide (NO)-releasing technologies have been explored to mitigate bacterial infections, particularly those stemming from common gram-positive and gram-negative bacterial pathogens. However, NO-releasing materials do not inherently possess anti-fouling capabilities.

Copper-Catalyzed Carbogermylation of Electron-Deficient Alkenes via 3,4- Difunctionalization of Quinoxalin-2(1H)-ones: Mechanistic Insights from Computational Studies.

Herein, we disclosed a copper-catalyzed carbogermylation of alkenes through 3,4-difunctionalization of quinoxalin-2(1H)-one to afford 3-oxo-3,4-dihydroquinoxaline 1-oxide incorporated organogermanium derivatives. Despite extensive research on the C-H functionalization of quinoxaline-2(1H)-one, the difunctionalization of this compound through C-C and N-O bond formation via the radical relay process is unusual. DFT calculation and mechanistic studies reveal that the reaction follows a radical pathway.