Publications by authors named "A G McCoy"
Objective: The objectives of this study are to synthesize findings from recent research of retrieval-augmented generation (RAG) and large language models (LLMs) in biomedicine and provide clinical development guidelines to improve effectiveness.
Materials And Methods: We conducted a systematic literature review and a meta-analysis. The report was created in adherence to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 analysis.
Article Synopsis
- - The study aimed to determine the reference interval (RI) for fecal calprotectin (fCP) levels and fCP:protein ratios in healthy horses to assess their potential for diagnosing intestinal inflammation in horses with colic and colitis.
- - Fecal samples were analyzed from 103 healthy horses and 28 horses with intestinal conditions, revealing that colitis cases had significantly higher fCP levels and fCP:protein ratios compared to healthy horses and colic cases.
- - The findings suggest that elevated fCP and fCP:protein ratios could be indicative of colitis but further research is necessary to develop reliable diagnostic tests for equine intestinal inflammation.
The development of perfusable and multiscale vascular networks remains one of the largest challenges in tissue engineering. As such, there is a need for the creation of customizable and facile methods to produce robustly vascularized constructs. In this study, secondarily crosslinkable (clickable) poly(ethylene glycol)-norbornene (PEGNB) microbeads were produced and evaluated for their ability to sequentially support suspension bioprinting and microvascular self-assembly towards the aim of engineering hierarchical vasculature.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how the acidity of a carboxylic acid group changes when it’s connected to a pyridinium cation through alkyl linkages of varying lengths.
- The researchers use cryogenic ion spectroscopy to measure the frequency changes of the acid’s OH stretches and find that shorter linkages increase acidity significantly, but this effect decreases with chain lengths around 4-5.
- Surprisingly, while OH stretches show a red shift, indicating increased acidity, the CO stretch shows a blue shift as the linkers get shorter, suggesting that the nearby cationic charge affects electron density differently than expected.
Equine gastrointestinal microbial communities vary across the gastrointestinal tract and in response to diet or disease. Understanding the composition and stability of gastric fluid microbiota in healthy horses is a prerequisite to understanding changes associated with the development of disease. The objective of this study was to describe microbial communities in the gastric fluid and feces of healthy horses longitudinally.
View Article and Find Full Text PDF