[Pathogenesis of lower limb diabetic angiopathies in patients with non-insulin-dependent diabetes mellitus].

Some indices of the system of homeostasis, lipid metabolism, lipid peroxidation (LPO), the levels of IRI, C-peptide, glycosylated Hb and glycemia (on an empty stomach) were investigated in 131 patients with noninsulin dependent diabetes mellitus (the patients ranged in age from 40 to 60). Correlation analysis has shown that derangements in the system of homeostasis, lipid metabolism and LPO are correlated and interrelated, resulting in disorder of the arterial blood flow in the lower limbs and hence to the development and progression of diabetic angiopathies. The authors have proposed a scheme of LPO involvement in the development of lower limb diabetic angiopathies.

[Use of logical decision rules during screening in order to identify groups at risk for diabetes mellitus].

The paper describes two-staged examination of population to detect diabetes mellitus using computerized methods and modern methods based on control theory. The authors present the results of screening population in one of the Moscow districts using a standard GTT with a logic decision rule to identify groups at high risk of developing diabetes mellitus. The efficacy of the rule and its use under actual conditions of limited resources were considered.

[Medico-genetic counselling of the relatives of patients with type I diabetes mellitus].

Population-genetic surveys show that for the relatives of patients with type I diabetes mellitus (the 1st degree of kinship) a risk of developing the same type of diabetes is 2-5%. Tables of repeated risk of developing diabetes mellitus (DM) of type I for persons with a different number of relatives affected by this type of DM were calculated on the basis of analysis of 2000 family histories of DM patients (a random sampling). A risk of developing this disease is in direct correlation with the number of sick and healthy relatives and their age.

[Genetic analysis of the structure of predisposition to diabetes mellitus. IV. Population-genetics study of two types of diabetes mellitus with onset at age 20-40].

It was found that age-specific morbidity risks of type I diabetes mellitus (DM I) increased from the age of 0-4 yrs (0.012-0.013%) to the age of 10-14 yrs (0.

[The interrelation of the glucose tolerance test indices with nutritional factors in persons with excess body weight].

An organized population of males aged 20 to 59 (799 persons) was investigated, of them 55 had excess body mass (EBM). Body mass was evaluated using Quetelet's rule, its values 30 and more being regarded as the presence of EBM in an examinee. Nutrition was investigated by a method of examination of food eaten up over a preceding day.