[An increase in the efficacy of psychopharmacotherapy of late-onset depressions: combination and substitution of antidepressants].

Objective: To comprehensively analyze the possibilities of using the methods of correction of non-effective psychopharmacotherapy of late-onset depressions.

Material And Methods: Methods of potentiating, combination and substitution of non-effective psychopharmacotherapy of late-onset depressions were studied.

Results And Conclusion: Indications to the use and specific algorithms of substitution and addition of antidepressants in non-effective psychopharmacotherapy of late-onset depressions have been developed.

[Complex cytogenetic aberrations in a patient with chronic myeloid leukemia: a case report].

In this article is presented a case of multiple chromosomal aberrations in a patient with CML accelerated phase. Cytogenetic and molecular cytogenetic studies allowed us to determine the presence of t(9;22)(q34;q11) and to identify additional abnormalities such as t(1;2)(p36;p21), del (6)(q21), +del(8)(q22), del(18)(q21), +der (22), some of which are not typical for this kind of neoplasia. This case is compared with publications of the same cases.

[Cardiomyoplasty--a surgical method of treatment in heart failure].

Until recently heart transplantation has been the only method of surgical treatment of severe myocardial heart failure. In the recent years operations of cardiomyoplasty have been performed more and more often for treatment of patients with this disease. The article presents the literature and personal data on the operation technique, indications and contraindications for it.

[Results of screening hematological and cytochemical blood studies of 906 children living in Bryansk Province at places with different intensities of soil contamination with cesium-137 and strontium-90].

Populations of children living in the Bryansk territory (radionuclide contamination 0.2-63.9 Cu/km2) are characterized by heterogeneous blood counts, though relevant mean values are close to control.

[Monoclonal immunophenotyping of acute lymphoblastic leukemia cells in children using rapid immune alkaline phosphatase].

Monoclonal immunophenotyping of leukemia cells of the bone marrow was carried out by the method of rapid immune alkaline phosphatase (RIAP) in 30 patients with acute lymphoblastic leukemia (ALL) aged 6 months-14 years. The authors used a panel of monoclonal antibodies (MCA) produced by Leu (Belgium) and DAKO (Denmark) directed to antigens of differentiation clusters: Tdt, HLA-DR, CD: 10, 19, 20, 22, 7, 8, 2, 5, 13, 33, 14. The results indicate diversity of compositions of differentiating antigens on leukemia cells of the dominant population and a different degree of leukemic cell pool heterogenicity.