Publications by authors named "A G Kudinova"
A new dual-functional implant based on gellan-xanthan hydrogel with calcium-magnesium silicate ceramic diopside and recombinant lysostaphin and bone morphogenetic protein 2 (BMP-2)-ray is developed. In this composite, BMP-2 is immobilized on microparticles of diopside while lysostaphin is mixed directly into the hydrogel, providing sustained release of BMP-2 to allow gradual bone formation and rapid release of lysostaphin to eliminate infection immediately after implantation. Introduction of diopside of up to 3% (w/v) has a negligible effect on the mechanical properties of the hydrogel but provides a high sorption capacity for BMP-2.
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- Childhood adversity is associated with lasting psychological and physical health issues, including obesity and metabolic diseases, which can be linked to epigenetic changes.
- In a study involving two cohorts, researchers found that those with early life stress showed increased biological aging (measured by GrimAge Acceleration) and higher BMI and insulin resistance, particularly related to experiences of abuse.
- The findings suggest that epigenetic factors and the interactions with obesity might play key roles in understanding how childhood adversity impacts long-term health outcomes.
Objectives: We aimed to characterize the interplay between early life stress (ELS), metabolic syndrome (MetS), and plasminogen activator inhibitor-1 (PAI-1), a major inhibitor of the fibrinolytic system implicated in cardiometabolic diseases. We also examined the understudied intersection of ELS, physical activity and PAI-1.
Methods: Healthy young adults ages 18-40 (N=200; 68% female) were recruited from the community.
[Assessment of the structural features of the hard palate in endonasal surgery].
Vestn Otorinolaringol
February 2024
Article Synopsis
- Research highlights that the anatomical features of the hard palate are not well-documented, leading to complications in nasal surgeries like perforation during christotomy.
- The study examined 107 patients using multispiral computed tomography (MSCT) to assess the hard palate's structure, focusing on thickness and width measurements.
- Results showed considerable variability in hard palate thickness (average 1.74 mm) and width (average 0.9 mm), suggesting these factors are important to consider for successful surgical interventions.