Publications by authors named "A G Komarova"
Article Synopsis
- The research investigates how different types of glial tumors in rats affect the attenuation coefficient of white matter in the brain, showing varied impacts based on tumor type and malignancy.
- Some tumors lead to a significant drop in this coefficient due to cell infiltration and damage to myelinated fibers, while others compress fibers without major destruction.
- The study also highlights the potential of using the attenuation coefficient, derived from OCT data, to identify late radiation damage in white matter, suggesting its usefulness for evaluating tissue health around tumors during surgeries.
The use of organic solvents in academic research and industry applications is facing increasing regulatory pressure due to environmental and health concerns. Consequently, there is a growing demand for sustainable solvents, particularly in the enzymatic synthesis and processing of polyesters. Biocatalysts offer a sustainable method for producing these materials; however, achieving high molecular weights often necessitates use of solvents.
View Article and Find Full Text PDFThe effects of cytotoxic chemotherapy on tumor vasculature and oxygenation are in the focus of modern investigations because vascular structure and distribution of oxygen influence tumor behavior and treatment response. The aim of our study was to monitor changes in the vascular component of colorectal tumor xenografts induced by a clinical combination of chemotherapy drugs FOLFOX in vivo using two complementary techniques: diffuse reflectance spectroscopy (DRS) and optical coherence tomography-based microangiography (OCT-MA). These techniques revealed a slower decrease in tumor blood oxygenation in treated tumors as compared to untreated ones, faster suppression of tumor vasculature perfusion and increase in water content as a result of treatment, and decrease in total hemoglobin in untreated tumors.
View Article and Find Full Text PDFArticle Synopsis
- Understanding how viruses like influenza A interact with cellular processes can help develop treatments targeting host cells.
- Researchers found that specific components of the Cullin 4-RING E3 ubiquitin ligases (CRL4), essential for virus replication, change their interactions during infection.
- The study revealed that IAV infection alters protein associations, impacting cellular functions such as protein folding and stress responses, which could lead to new antiviral strategies.
Significance: Autofluorescence characteristics of the reduced nicotinamide adenine dinucleotide and oxidized flavin cofactors are important for the evaluation of the metabolic status of the cells. The approaches that involve a detailed analysis of both spectral and time characteristics of the autofluorescence signals may provide additional insights into the biochemical processes in the cells and biological tissues and facilitate the transition of spectral fluorescence lifetime imaging into clinical applications.
Aim: We present the experiments on multispectral fluorescence lifetime imaging with a detailed analysis of the fluorescence decays and spectral profiles of the reduced nicotinamide adenine dinucleotide and oxidized flavin under a single excitation wavelength aimed at understanding whether the use of multispectral detection is helpful for metabolic imaging of cancer cells.