[Combined prevention of infectious complications of minimally invasive procedures in urology].

The available literature data on the prevention of infectious and inflammatory complications after minimally invasive urological procedures based on current knowledge about urobiome as the main point of application of preventive measures are summarized in the article. The main risk factors for the occurrence of inflammatory complications at all stages of the perioperative process are analyzed. The role of antibacterial prophylaxis is emphasized, and its features and the importance of finding ways to overcome one of the main problems of modern medicine, which is antibiotic resistance, are discussed.

Evaluation of Eukaryotic mRNA Coding Potential.

It is widely discussed that eukaryotic mRNAs can encode several functional polypeptides. Recent progress in NGS and proteomics techniques has resulted in a huge volume of information on potential alternative translation initiation sites and open reading frames (altORFs). However, these data are still incomprehensive, and the vast majority of eukaryotic mRNAs annotated in conventional databases (e.

Articulatory Insights into the L2 Acquisition of English-/l/ Allophony.

In many English varieties, /l/ is produced differently in onsets and codas. Compared with "light" syllable-initial realizations, "dark" syllable-final variants involve reduced tongue tip-alveolar ridge contact and a raised/retracted tongue dorsum. We investigate whether native French and Spanish speakers whose L1 lacks such positionally conditioned variation can acquire English-/l/ allophony, testing the hypotheses that (1) the allophonic pattern will be acquired by both groups but (2) learners will differ from native speakers in their phonetic implementation, particularly in codas; and (3) French-speaking learners will outperform their Spanish-speaking counterparts.

[Abnormal mTOR Signaling Pathway Activity in Autism Spectrum Disorders: Prospects of Mechanism-Based Therapy].

Autism spectrum disorder (ASD) is a developmental disorder characterized by the early onset of problems with communication, learning, and behavior. The syndromic form of ASD is caused by monogenic mutations. When it is not possible to find genetic or other known mechanisms, the term "idiopathic autism" is used.