Unlocking the therapeutic potential of canagliflozin in NAFLD: Insights into AMPK/SIRT1-mediated lipophagy.

Unlabelled: Nonalcoholic fatty liver disease (NAFLD) is a rising global health problem. The antidiabetic canagliflozin (CANA) has been proposed to ameliorate the metabolic abnormalities in NAFLD.

Aim: This study aimed to explore the possible anti-NAFLD effects of CANA in rats and HepG2 cells, focusing on AMPK/SIRT1-mediated lipophagy.

The role of neutrophilia in hyperlactatemia, blood acidosis, impaired oxygen transport, and mortality outcome in critically ill COVID-19 patients.

Introduction: COVID-19 severity and high in-hospital mortality are often associated with severe hypoxemia, hyperlactatemia, and acidosis, yet the key players driving this association remain unclear. It is generally assumed that organ damage causes toxic acidosis, but since neutrophil numbers in severe COVID-19 can exceed 80% of the total circulating leukocytes, we asked if metabolic acidosis mediated by the glycolytic neutrophils is associated with lung damage and impaired oxygen delivery in critically ill patients.

Methods: Based on prospective mortality outcome, critically ill COVID-19 patients were divided into ICU- survivors and ICU-non-survivors.

A review of recent progress in alginate-based nanocomposite materials for tissue engineering applications.

Integrating nanotechnology with tissue engineering has revolutionized biomedical sciences, enabling the development of advanced therapeutic strategies. Tissue engineering applications widely utilize alginate due to its biocompatibility, mild gelation conditions, and ease of modification. Combining different nanomaterials with alginate matrices enhances the resulting nanocomposites' physicochemical properties, such as mechanical, electrical, and biological properties, as well as their surface area-to-volume ratio, offering significant potential for tissue engineering applications.

Effects of Varying Light Durations on Sperm Quality in Rams.

This investigation aimed to study the effects of varying light exposure durations on ram sperm. A total of 25 rams were randomly divided into five groups. The control group was exposed to light durations of 12 h, while the experimental groups were exposed to light durations of 14, 16, 18, and 20 h.

Predictors of renal outcomes and mortality in patients with renal vein thrombosis: a retrospective multicenter study.

Background: Studies on renal vein thrombosis have been conducted as case reports or case series. The renal outcomes and mortality risk of renal vein thrombosis have not been fully established. We aimed to investigate the clinical characteristics, treatment modalities, and predictors of renal outcomes and mortality in patients with renal vein thrombosis in a large multicenter cohort.