Publications by authors named "A G Good"
p53 is a potent transcription factor that is crucial in regulating cellular responses to stress. Mutations in the gene are found in >50% of human cancers, predominantly occurring in the DNA-binding domain (amino acids 94-292). The Y220C mutation accounts for 1.
View Article and Find Full Text PDFCardiovascular diseases resulting from myocardial infarction (MI) remain a leading cause of death worldwide, imposing a substantial burden on global health systems. Current MI treatments, primarily pharmacological and surgical, do not regenerate lost myocardium, leaving patients at high risk for heart failure. Engineered heart tissue (EHT) offers a promising solution for MI and related cardiac conditions by replenishing myocardial loss.
View Article and Find Full Text PDFNuclear speckles are dynamic nuclear bodies characterized by high concentrations of factors involved in RNA production. Although the contents of speckles suggest multifaceted roles in gene regulation, their biological functions are unclear. Here we investigate speckle variation in human cancer, finding two main signatures.
View Article and Find Full Text PDFArticle Synopsis
- - The SingWell Project aims to investigate whether group singing can improve speech-in-noise perception and overall mental health in older adults experiencing unaddressed hearing loss, addressing gaps in previous studies.
- - The study will involve 210 participants aged 60 and above, who will be randomly assigned to either a group singing program or an audiobook club for 12 weeks, with various assessments conducted throughout.
- - Researchers anticipate that engaging in group singing will significantly enhance both communication abilities in noisy environments and participants' psychosocial wellbeing.
Article Synopsis
- Glucose is crucial for pancreatic β cell function and understanding how it influences these cells could lead to new treatments for type 2 diabetes (T2D).
- The RNA-binding protein PCBP2 is essential for β cell function, especially during high glucose conditions, as it helps regulate insulin secretion and the expression of related genes.
- Research shows that PCBP2 levels increase in response to glucose but decrease in T2D patients, linking it to gene changes that are important for β cell activity and overall insulin regulation.