Publications by authors named "A G Ghielmetti"
Background: After denosumab (Dmab) discontinuation C-terminal telopeptide (CTX) levels increase, bone mineral density (BMD) decreases and multiple vertebral fractures (FX) may occur with relevant impacts on women's health. A sequential therapy with bisphosphonates is recommended, and the European Calcified Tissue Society (ECTS) proposed repeated zoledronate (ZOL) administrations in patients with persistently high CTX levels, although the efficacy of this schedule is unknown. In this retrospective study, we describe BMD changes and FX rate in 52 patients managed according to the ECTS recommendations.
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- - The study investigates skeletal outcomes in long-term lung transplant survivors, comparing those with cystic fibrosis (CF) and other lung diseases (nCF), focusing on fragility fractures (FX) and bone health after two years post-transplant.
- - Results show that after the initial two years post-transplant, the rate of fractures decreased significantly to 4.4%, with no substantial difference found between CF and nCF patients.
- - Bone mineral density (BMD) and trabecular bone score (TBS) remained stable across both groups, indicating that skeletal complications become less common and are similar in frequency for both types of patients after the second year.
Stimuli-responsive polymers are of great interest due to their ability to translate changing environmental conditions into responses in defined materials. One possibility to impart such behavior is the incorporation of optically active molecules into a polymer host. Here, we describe how sensor molecules that consist of a π-extended benzothiadiazole emitter and a naphthalene diimide quencher can be exploited in this context.
View Article and Find Full Text PDFContext: Cushing's syndrome frequently causes mental health impairment. Data in patients with adrenal incidentaloma (AI) are lacking.
Objective: We aimed to evaluate psychiatric and neurocognitive functions in AI patients, in relation to the presence of subclinical hypercortisolism (SH), and the effect of adrenalectomy on mental health.