Health Syst (Basingstoke)
October 2024
Effective radiotherapy for cancer treatment requires precise and reproducible positioning of patients at linear accelerators. Assistance systems in digitally networked radiotherapy can help involved specialists perform these tasks more efficiently and accurately. This paper analyses patient positioning systems and develops new knowledge by applying the Design Science Research methodology.
View Article and Find Full Text PDFBackground: Osteogenesis imperfecta (OI) is a genetic defect in collagen type I, phenotypically characterized by bony fragility and a propensity to high rates of childhood fracture. Fragility fractures in patients with OI have been reported with routine hospital care. In addition, there is a nonzero rate of iatrogenic fracture during orthopaedic surgery directly related to the technical steps of the procedure itself.
View Article and Find Full Text PDFPurpose: To assess the safety and efficacy of AAV5-hRKp.RPGR in participants with retinitis pigmentosa GTPase regulator (RPGR)-associated X-linked retinitis pigmentosa (XLRP).
Design: Open-label, phase 1/2 dose escalation/expansion study (ClinicalTrials.