HDAC8 as an emerging target in drug discovery with special emphasis on medicinal chemistry.

HDAC8 catalyzes the deacetylation of both histones and nonhistone proteins. The abnormal expression of HDAC8 is associated with various pathological conditions causing cancer and other diseases like myopathies, Cornelia de Lange syndrome, renal fibrosis, and viral and parasitic infections. The substrates of HDAC8 are involved in diverse molecular mechanisms of cancer such as cell proliferation, invasion, metastasis and drug resistance.

Bilateral seminoma in a duck (Anas platyrhynchos).

A case of bilateral seminoma in an aged Mallard duck (Anas platyrhynchos) is described. Both testes were enlarged. Historically, the testes revealed large irregular seminiferous tubules containing diffuse sheets of large round, hyperchromatic neoplastic spermatogenic cells.