In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections.

Endovascular repair of aortic dissection still presents significant limitations. Preserving the mechanical and biological properties set by the aortic microstructure is critical to the success of implantable grafts. In this paper, we present the performance of an adhesive bioresorbable patch designed to cover the entry tear of aortic dissections.

Unravelling the many facets of human cooperation in an experimental study.

Humans readily cooperate, even with strangers and without prospects of reciprocation. Despite thousands of studies, this finding is not well understood. Most studies focussed on a single aspect of cooperation and were conducted under anonymous conditions.

Acute Stent-Induced Endothelial Denudation: Biomechanical Predictors of Vascular Injury.

Recent concern for local drug delivery and withdrawal of the first Food and Drug Administration-approved bioresorbable scaffold emphasizes the need to optimize the relationships between stent design and drug release with imposed arterial injury and observed pharmacodynamics. In this study, we examine the hypothesis that vascular injury is predictable from stent design and that the expanding force of stent deployment results in increased circumferential stress in the arterial tissue, which may explain acute injury poststent deployment. Using both numerical simulations and experiments on three different stent designs (slotted tube, corrugated ring, and delta wing), arterial injury due to device deployment was examined.

Testosterone effects on functional amygdala lateralization: A study in adolescent transgender boys and cisgender boys and girls.

The influence of testosterone on the development of human brain lateralization has been subject of debate for a long time, partly because studies investigating this are necessarily mostly correlational. In the present study we used a quasi-experimental approach by assessing functional brain lateralization in trans boys (female sex assigned at birth, diagnosed with Gender Dysphoria, n = 21) before and after testosterone treatment, and compared these results to the functional lateralization of age-matched control groups of cisgender boys (n = 20) and girls (n = 21) around 16 years of age. The lateralization index of the amygdala was determined with functional magnetic resonance imaging (fMRI) during an emotional face matching task with angry and fearful faces, as the literature indicates that boys show more activation in the right amygdala than girls during the perception of emotional faces.

The Effect of Prosthetic Alignment on Prosthetic and Total Leg Stiffness While Running With Simulated Running-Specific Prostheses.

Running-specific prostheses (RSP) are designed to replicate the spring-like behavior of the biological leg in people with a lower limb amputation. Running performance strongly depends on stiffness of the RSP. The aim of this study was to investigate the effects of angle of alignment of the RSP on its stiffness, and how this affects total leg stiffness and the gait pattern during running.