Summary of a Consensus Conference on the Management of Highly Sensitized Multiorgan Transplant Candidates.

The number of highly sensitized patients in need of a multiorgan transplant is increasing. Criteria informing their transplant candidacy, approaches to management on the waitlist, and protocols related to alloantibody monitoring vary widely. We convened a consensus conference to discuss these different practices in the United States and the United Kingdom and to review the contemporary outcomes of these challenging cases.

Benefits of a Virtual, Adapted Yoga Practice for People With Aphasia: A Pilot Cohort Study.

Purpose: The purpose of this study was to extend previous work using a pilot delayed cohort design with a more geographically and linguistically diverse group of people with aphasia (PWA) to explore the impact of a virtual, adapted, and aphasia-friendly yoga program; expand our original outcome measures to include a self-report of aphasia impact in addition to measures of resilience, stress, sleep disturbance, and pain management; and continue programmatic development through participant feedback about the program structure.

Method: A delayed cohort design was used to document the benefits of a virtual, adapted, and aphasia-friendly yoga program for persons with moderate-severe aphasia, replicating our previous work with persons with mild-moderate aphasia. Fourteen PWA participated in an 8-week community yoga program.

Audiological profile of first-time hearing aid users - implications for the development of a fast-track fitting protocol.

Objective: To assess the feasibility of implementing a fast-track process (single-session assess-and-fit appointment with no ENT specialist's examination) in hearing rehabilitation by investigating the accuracy of the protocol assignment applying various cut-off criteria and describing the audiometric profile of patients being evaluated for their first hearing aids.

Design: Retrospective chart review.

Study Sample: Patients from a single institution (n = 1807, median age 75 years, IQR 67-82 years) undergoing the evaluation for their first hearing aid fitting.

Fellowship training for cellular therapy laboratory directors.

The rapidly evolving field of cell and gene therapy (CGT) demands a new generation of leaders capable of managing complex manufacturing processes while navigating stringent regulatory environments. To address this need, Mayo Clinic established a Cellular Therapy Fellowship (CTF) program specifically designed to train future laboratory directors by integrating hands-on manufacturing experience with didactic instruction in laboratory management, quality systems, and regulatory science. The CTF curriculum includes structured rotations through cleanroom manufacturing, quality assurance, and process development groups.

Phase I study of pembrolizumab in combination with ibrutinib for the treatment of unresectable or metastatic melanoma.

Background: Immune checkpoint inhibitors (ICIs) have been transformative in the treatment of patients with metastatic melanoma, but primary and secondary resistance to ICI treatment is common. One key mechanism for ICI resistance is the skewing of the immune response from a cytotoxic (Th1) to a chronic inflammatory (Th2) profile. The small molecule ibrutinib is a dual-target agent that inhibits Bruton's Tyrosine Kinase (BTK) and Interleukin-2-inducible T-cell Kinase (ITK), a key regulator of Th2 immunity.