Publications by authors named "A G Christophersen"
Article Synopsis
- In vitro models studying autoimmunity often lack the complex immune environment and epithelial interactions necessary for accurate research, particularly regarding coeliac disease (CeD), which involves gluten triggering immune responses.
- Researchers created air-liquid interface (ALI) duodenal organoids from biopsies, preserving both epithelial cells and local immune cells, allowing for a more realistic study of CeD.
- The findings highlighted that gluten peptides led to significant epithelial damage in CeD organoids, mediated by immune responses including the action of IL-7, a critical factor in the disease's pathology, especially in active cases compared to those on gluten-free diets.
Autoantibodies against the enzyme transglutaminase 2 (TG2) are characteristic of celiac disease (CeD), and TG2-specific immunoglobulin (Ig) A plasma cells are abundant in gut biopsies of patients. Here, we describe the corresponding population of autoreactive B cells in blood. Circulating TG2-specific IgA cells are present in untreated patients on a gluten-containing diet but not in controls.
View Article and Find Full Text PDFBackground & Aims: The treatment of celiac disease (CeD) with gluten-free diet (GFD) normalizes gut inflammation and disease-specific antibodies. CeD patients have HLA-restricted, gluten-specific T cells persisting in the blood and gut even after decades of GFD, which are reactivated and disease driving upon gluten exposure. Our aim was to examine the transition of activated gluten-specific T cells into a pool of persisting memory T cells concurrent with normalization of clinically relevant biomarkers during the first year of treatment.
View Article and Find Full Text PDFBackground: Patients with lung cancer exhibit increased risk of pulmonary embolism (PE). While the contrast phase of computed tomography of the chest in the diagnostic work-up of suspected chest malignancy does not allow reliable detection of PE, it may be feasible to screen for present PE during endobronchial ultrasound (EBUS) examination.
Objectives: The aim of this study was to establish if screening during EBUS for PE in patients with suspected lung cancer is feasible and if positive findings are predictive of PE.
CD4 T cells specific for cereal gluten proteins are key players in celiac disease (CeD) pathogenesis. While several CeD-relevant gluten T cell epitopes have been identified, epitopes recognized by a substantial proportion of gluten-reactive T cells remain unknown. The identification of such CeD-driving gluten epitopes is important for the food industry and in clinical settings.
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