Publications by authors named "A G Christodoulou"
Purpose To evaluate the performance of a high-dynamic-range quantitative susceptibility mapping (HDR-QSM) cardiac MRI technique to detect intramyocardial hemorrhage (IMH) and quantify iron content using phantom and canine models. Materials and Methods A free-running whole-heart HDR-QSM technique for IMH assessment was developed and evaluated in calibrated iron phantoms and 14 IMH female canine models. IMH detection and iron content quantification performance of this technique was compared with the conventional iron imaging approaches, R2*(1/T2*) maps, using measurements from ex vivo imaging as the reference standard.
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- This study aims to reduce the time needed for Chemical Exchange Saturation Transfer (CEST) imaging by using a method that combines Z-spectrum undersampling with deep learning to create accurate CEST maps.* -
- The research involved a U-NET neural network trained on data from 18 volunteers to effectively generate CEST maps even from significantly undersampled images, showcasing notable improvements over traditional models.* -
- Results indicated that the U-NET can reduce scan time by up to 3.5 times while maintaining reliable accuracy in CEST measurements, making it a promising approach for future imaging studies, including those focused on glioblastoma.*
: Recent studies have focused on the association between the risk of diabetic retinopathy (DR) and the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene; however, their results remain inconclusive. Thus, a systematic review and meta-analysis were carried out to clarify the role of these polymorphisms in the development of DR. : A systematic search of electronic databases (PubMed, Scopus, and Cochrane Library) was conducted until 25 June 2024, and a reference list of relevant articles was collected, which explored the association between the rs1501299 and rs2241766 polymorphisms of the ADIPOQ gene and the risk of DR.
View Article and Find Full Text PDFBackground: Vaccination uptake is a complex behavior, influenced by numerous factors. Behavioral science theories are commonly used to explain the psychosocial determinants of an individual's health behavior. This study examined the behavioural, cognitive, and emotional determinants of COVID-19 vaccination intention based on well-established theoretical models: Acceptance and Commitment Therapy (ACT), Capability, Opportunity, Motivation, and Behaviour (COM-B) and the Health Belief Model (HBM).
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- The study introduces a new MR Multitasking (MT) technique designed to enhance radiotherapy treatment planning for abdominal sites by providing motion-resolved and multi-contrast images in a single scan.
- The MT technique employs advanced imaging methods to accurately capture motion and structural details, showing promising results in both digital simulations and real patient studies, with favorable correlations to traditional imaging methods.
- Initial clinical evaluations indicate that the MT technique allows for effective target delineation, suggesting that it could simplify and improve the abdominal radiotherapy planning process.