Publications by authors named "A G Chapuis"
Acute myeloid leukemia (AML) that is relapsed and/or refractory post-allogeneic hematopoietic cell transplantation (HCT) is usually fatal. In a prior study, we demonstrated that AML relapse in high-risk patients was prevented by post-HCT immunotherapy with Epstein-Barr virus (EBV)-specific donor CD8 T cells engineered to express a high-affinity Wilms Tumor Antigen 1 (WT1)-specific T-cell receptor (TTCR- C4). However, in the present study, infusion of EBV- or Cytomegalovirus (CMV)-specific T did not clearly improve outcomes in fifteen patients with active disease post-HCT.
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- - Immune effector cell-associated hematotoxicity (ICAHT) significantly affects patients undergoing CAR T-cell therapy, and the factors linked to severe forms of it are not well understood.
- - Researchers identified key pre-infusion and post-infusion factors that predict early severe ICAHT in a study involving 691 patients; these included disease type, blood counts, inflammatory and coagulopathy markers.
- - Two predictive models (eIPMPre and eIPMPost) were developed and validated, showing strong accuracy in predicting severe ICAHT, with the post-infusion model being particularly effective; an online tool for individualized predictions is available for use.
Article Synopsis
- * Current TCRs targeting G12-mutant KRAS are limited, but researchers found that tumor cells might evade immune attack by presenting a modified, methylated version of the KRAS epitope instead of the unaltered one.
- * A new approach was used to create TCRs that can recognize this methylated peptide, and a gene screen identified a protein called SPT6 that plays a role in the methylation process, indicating a potential strategy to enhance TCR-T cell therapies by targeting these modifications
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- The study investigates the immune response to HSV-2 reactivation by examining T cells in skin biopsies and blood samples before and after vaccination with an HSV-2 candidate vaccine (HSV529).
- After the first vaccine dose, there was a notable increase in HSV-2-specific CD4+ T cell sequences from blood that made their way into the skin, indicating a successful immune memory response.
- Unique T cell clones were identified in the skin that weren't found in the blood, suggesting that the skin has a distinct immune profile, and highlights the importance of studying tissue-specific immunity in vaccine responses.
Dewatering is a critical step in cassava flours processing. Compression dewatering kinetics are useful to understand and design a dewatering operation. The dataset presents dewatering kinetics measured in a filtration-consolidation cell at constant pressure between 4 and 21 bar, on several cassava mashes (three batches fragmented at two particle size distributions (PSDs)).
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