Publications by authors named "A G Bot"
Importance: Infective endocarditis (IE) caused by Staphylococcus aureus is associated with high mortality, approximately 20% to 30%, mostly in the first month, with no improvement in recent decades. Current opinion is that antistaphylococcal penicillin and cefazolin are equally effective in treating methicillin-susceptible S aureus (MSSA) IE, and both are recommended as possible first-line treatments. Most MSSA strains carry the β-lactamase blaZ gene, and some blaZ-positive strains exhibit an inoculum effect, meaning increased minimum inhibitory concentrations at high inoculum.
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- MAGE-A is a cancer-associated antigen expressed in various tumors but has limited presence in normal tissues; this study focused on its expression in urinary bladder and lung cancers while evaluating the immune environment.
- The researchers analyzed MAGE-A and PD-L1 levels in tumor samples using immunohistochemistry and RNA sequencing, finding that 57% of samples showed detectable MAGE-A expression, with no significant difference between the two cancer types.
- Treatment with checkpoint inhibitors did not alter MAGE-A expression or other immune markers in urothelial carcinoma, suggesting that previous tumor samples can still be useful for evaluating MAGE-targeted treatments.
Objectives: This study aims to assess the urinary diffusion and clinical effectiveness of voriconazole in patients with fluconazole-resistant urinary candidiasis.
Patients And Methods: In this prospective pilot study, we utilized a validated chromatography method to measure voriconazole in urine over a 12-hour period between two administrations of the drug and in plasma at trough.
Results: Thirty-five patients, including five with fluconazole-resistant urinary candidiasis, were included.
The phase behavior is investigated for systems composed of a large number of macromolecular components , with ≥ 2. Liquid-liquid phase separation is modeled using a virial expansion up to the second order of the concentrations of the components. Formal analytical expressions for the spinodal manifolds in dimensions are derived, which simplify their calculation (by transforming the original problem into inequalities that can be evaluated numerically using linear programming techniques).
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