Publications by authors named "A G Bhasker"
Global obesity rates have risen dramatically, now exceeding deaths from starvation. Metabolic and bariatric surgery (MBS), initially for severe obesity (BMI ≥35 kg/m), is performed globally over 500 000 times annually, offering significant metabolic benefits beyond weight loss. However, varying eligibility criteria globally impact patient care and healthcare resources.
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- One anastomosis gastric bypass (OAGB) is a recognized method in metabolic and bariatric surgery, making up 7.6% of global procedures, but still has several ongoing controversies despite its approval as a standalone procedure.
- A modified Delphi consensus was conducted with 86 experts from 25 countries, addressing 29 key questions about patient selection and surgical standards, achieving agreement on 22 items, including patient suitability and post-operative care protocols.
- Important findings include that OAGB is suitable for adolescents over 15 and those with class 1 obesity with uncontrolled type 2 diabetes, while highlighting the need for tailored surgical practices and continued research for better patient outcomes.
Background: The purpose of this study was to assess the impact of metabolic and bariatric surgery (MBS) on Quality of Life (QoL) in Indian patients with obesity over 10 years.
Methods: A retrospective chart review was conducted at 11 centres for individuals with MBS between February 2013 and May 2022. Patient medical records provided the source of de-identified data.
Based on recent genome-wide association studies, it is theorized that altered regulation of autophagy contributes to the pathophysiology of schizophrenia and bipolar disorder. As activity of autophagy-regulatory pathways is controlled by discrete phosphorylation sites on the relevant proteins, phospho-protein profiling is one of the few approaches available for enabling a quantitative assessment of autophagic activity in the brain. Despite this, a comprehensive phospho-protein assessment in the brains of schizophrenia and bipolar disorder subjects is currently lacking.
View Article and Find Full Text PDFUnlabelled: Exchange proteins directly activated by cAMP (EPAC) belong to a family of RAP guanine nucleotide exchange factors (RAPGEF). EPAC1/2 (RAPGEF3/4) activates RAP1 and the alternative cAMP signaling pathway. We previously showed that the differential growth response of primary and metastatic melanoma cells to cAMP is mediated by EPAC.
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