Publications by authors named "A G Amiryan"
Objective: To analyse ocular and systemic findings of patients presenting with systemic metastasis.
Methods And Analysis: It is an international, multicentre, internet-enabled, registry-based retrospective data analysis. Patients were diagnosed between 2001 and 2011.
Article Synopsis
- The study involved creating an intraocular retinoblastoma model using 4 mature BALB/c nude mice, with retinoblastoma cells injected into each of their eyes.
- The injections were carefully performed with a microscope to place a specific volume of cancer cells into the subretinal space.
- After a follow-up period, tumors were successfully visualized and identified in two of the mice, indicating that this model can aid future research and drug testing for retinoblastoma.
We present a method for recovery of narrow homogeneous spectral features out of a broad inhomogeneous overlapped profile based on second-derivative processing of the absorption spectra of alkali metal atomic vapor nanocells. The method is shown to preserve the frequency positions and amplitudes of spectral transitions, thus being applicable for quantitative spectroscopy. The proposed technique was successfully applied and tested for measurements of hyperfine splitting and atomic transition probabilities, development of an atomic frequency reference, determination of isotopic abundance, study of atom-surface interaction, and determination of magnetic-field-induced modification of atomic transition frequency and probability.
View Article and Find Full Text PDFThe study presents clinical and genetic analysis of a case of unilateral multifocal uveal choroidal melanoma in a patient of 67 years. Results of ophthalmoscopy, echography, fluorescent angiography, optical coherence tomography are described. Molecular genetic testing of peripheral blood samples was performed, including detection of the occurrences of CC genotype in C3435T polymorphism of the gene ABCB1/MDR1 associated with unfavorable vital prognosis.
View Article and Find Full Text PDFAim: to analyze survival rates in uveal melanoma (UM) patients and establish correlations with chromosome 3 monosomy, chromosome 1p deletion, and RASSF1A methylation.
Material And Methods: Methylation-specific PCR analysis was performed in 104 patients with histologically verified UM.
Results: A statistically significant correlation has been found between chromosome 3 monosomy, on the one hand, and mixed/epithelioid cell melanomas and ciliary body involvement, on the other.