Oral vs. Outpatient Parenteral Antimicrobial Treatment for Infective Endocarditis: Study Protocol for the Spanish OraPAT-IE GAMES Trial.

Introduction: The POET trial demonstrated that moving from intravenous to oral antibiotics in stable patients with left-sided infective endocarditis (IE) was noninferior to fully parenteral treatment. However, it did not compare outpatient strategies.

Methods: The OraPAT-IE GAMES trial is a noninferiority, multicenter, randomized, open-label study aimed to compare partial oral versus outpatient parenteral antibiotic therapy (OPAT) for consolidation of antibiotic treatment in left-sided IE.

Cranial ultrasound in neonatal brain infections.

Infection of the neonatal central nervous system (CNS) can cause irreversible brain damage. Cranial ultrasound is an important neuroimaging modality in the neonatal period for detecting brain injury. Several types of organism can cause neonatal CNS infection.

Prediction of monocular defocus curves in pseudophakia with different pupil sizes.

Existing models for predicting clinical visual acuity (VA) following lens replacement surgery use controlled experimental conditions where pupil size is typically fixed. However, pupil size may influence visual performance depending on the design of the intraocular lens (IOL) implanted. This study compares optical bench testing metrics to clinical VA in pseudophakic patients with different pupil sizes and IOL models.

European training requirements in Neonatology 2021-towards a unified training standard for Neonatologists.

The European Society for Paediatric Research (ESPR) first developed recommendations for a Neonatology specific European training curriculum in 1998, with updates in 2007 and 2021. The aim of these recommendations was to define a common, European standard of training for national educational programmes for Neonatologists. Following the Union of European Medical Specialists' (UEMS) framework of European Training Requirements (ETR), and similar to the American Board of Pediatrics (ABP) recommendations, graduates of training programmes conforming to the ETR will be eligible throughout Europe for recognition of equality of training, and with that should be enabled to freedom-of-movement.

Long-Term Outcomes of Surgical Decompression in Treating Calcifying Odontogenic Cyst Associated With Compound Odontoma: A 9-Year Follow-Up Case Report and Literature Review.

A calcifying odontogenic cyst (COC) is a cystic lesion originating from odontogenic epithelium, exhibiting ameloblastomatous features and containing focal accumulations of ghost cells. The standard treatment for COC typically involves enucleation followed by surgical curettage. However, if the cyst is large or closely associated with anatomical structures, decompression may be considered as a preliminary step before enucleation.