Three-year questionnaire study on human papillomavirus vaccination targeting new female college school students: Follow-up to a 2021 report to reveal the impact of a policy change in Japan.

Aim: The purpose of this study was to examine the trend in human papillomavirus (HPV) vaccination rates in Japan before and after a policy change in 2022, involving resumption of active recommendation and start of catch-up vaccination.

Methods: From 2021 to 2023, a web-based questionnaire survey was administered to newly enrolled female college students in Yokohama, Japan. The questionnaire included items such as age, HPV vaccination status, HPV vaccine awareness, and awareness of catch-up vaccination.

Neuronal Excitation Induces Tau Protein Dephosphorylation via Protein Phosphatase 1 Activation to Promote Its Binding with Stable Microtubules.

The tau protein is a microtubule-associated protein that promotes microtubule stabilization. The phosphorylation of the tau protein has been linked to its dissociation from microtubules. Here, we examined the relationship between neuronal depolarization activity and tau protein phosphorylation by employing model systems in culture as well as in vivo.

Transient sleep apnea results in long-lasting increase in β-amyloid generation and tau hyperphosphorylation.

Sleep apnea is regarded as an important risk factor in the pathogenesis of Alzheimer disease (AD). Chronic intermittent hypoxia treatment (IHT) given during the sleep period of the circadian cycle in experimental animals is a well-established sleep apnea model. Here we report that transient IHT for 4 days on AD model mice causes Aβ overproduction 2 months after IHT presumably via upregulation of synaptic BACE1, side-by-side with tau hyperphosphorylation.

Third international challenge to model the medium- to long-range transport of radioxenon to four Comprehensive Nuclear-Test-Ban Treaty monitoring stations.

In 2015 and 2016, atmospheric transport modeling challenges were conducted in the context of the Comprehensive Nuclear-Test-Ban Treaty (CTBT) verification, however, with a more limited scope with respect to emission inventories, simulation period and number of relevant samples (i.e., those above the Minimum Detectable Concentration (MDC)) involved.

Validity of the source term for the Fukushima Dai-ichi Nuclear Power Station accident estimated using local-scale atmospheric dispersion simulations to reproduce the large-scale atmospheric dispersion of Cs.

The source term of Cs from the Fukushima Dai-ichi Nuclear Power Station (FDNPS) accident was estimated from the results of local-scale atmospheric dispersion simulations and measurements. To confirm the source term's validity for reproducing the large-scale atmospheric dispersion of Cs, this study conducted hemispheric-scale atmospheric and oceanic dispersion simulations. In the dispersion simulations, the atmospheric-dispersion database system Worldwide version of System for Prediction of Environmental Emergency Dose Information (WSPEEDI)-DB and oceanic dispersion model SEA-GEARN-FDM that were developed by the Japan Atomic Energy Agency were used.