Publications by authors named "A Fujito"
Article Synopsis
- 5-Fluorouracil (5-FU) causes pigmentation in patients, negatively affecting their quality of life, but the underlying mechanism is not fully understood.
- During a study using male HRM-2 hairless mice, researchers observed increased melanin accumulation and blood vessel activity in the skin after 8 weeks of 5-FU treatment.
- Unlike other chemotherapy drugs like cytarabine and irinotecan, 5-FU specifically leads to hyperpigmentation, suggesting a link between 5-FU, tyrosinase activity, and blood vessel enhancement.
Article Synopsis
- Anticancer drugs, including 5-fluorouracil (5-FU), often cause skin pigmentation as a side effect, negatively impacting patients' quality of life (QOL).
- This study aimed to uncover the mechanism behind 5-FU-induced skin pigmentation using specific mice models that were treated with the drug for 8 weeks.
- The findings revealed that the pigmentation process involves an oxidative stress/NF-κB/ACTH/cAMP/tyrosinase pathway, which can be inhibited to reduce pigmentation in 5-FU-treated mice.
Renal cell carcinoma (RCC) is the most common malignancy of kidney and remains largely intractable once it recurs after resection. mTOR inhibitors have been one of the mainstays used against recurrent RCC; however, there has been a major problem of the resistance to mTOR inhibitors, and thus new combination treatments with mTOR inhibitors are required. We here retrospectively showed that regular use of antilipidemic drug statins could provide a longer progression free survival (PFS) in RCC patients prescribed with an mTOR inhibitor everolimus than without statins (median PFS, 7.
View Article and Find Full Text PDFBackground: The present study was undertaken to examine the correlation between serum levels of adiponectin isoforms and the risk for endometrial cancer.
Methods: This retrospective case-control study included 43 Japanese women with endometrial cancer and 62 Japanese women with no history of cancer. Serum levels of total adiponectin and the respective isoforms were determined by enzyme-linked immunosorbent assay.
Objectives: The aim of this study was to assess the prognostic factor of radical surgery in patients with stage IIIc ovarian cancer.
Study Design: Fifty-two patients were subjected to the study. The complete resection or optimal primary cytoreductive surgery (OPCS) was set as the maximum effort, and the accomplishment rate and prognosis were assessed.