Publications by authors named "A Freire-Goncalves"

Article Synopsis
  • - Corticobasal syndrome is mainly sporadic but can have familial genetic cases linked to various gene variants, including GRN, MAPT, and c9orf72.
  • - A case study of a 57-year-old woman revealed symptoms like speech impairment, rigidity, and tremors, alongside MRI findings of left side brain atrophy and a SQSTM1 P392L genetic variant.
  • - This case adds new insights into the range of symptoms linked to SQSTM1 variants and highlights the potential role of the ubiquitin-proteasome system in corticobasal syndrome.
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Objective: To evaluate the potential of neuroimaging, serum biomarkers, stroke etiology, and clinical characteristics as predictors of upper limb functioning 12 weeks after stroke.

Methods: This was a prospective, observational study of patients (18-85 years-old) hospitalized due to acute ischemic stroke in the territory of the middle cerebral artery. Patients were hospitalized at a stroke rehabilitation center, where they underwent a standardized rehabilitation program.

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Background: Stroke is one of the leading causes of disability worldwide. Early prediction of poststroke disability using clinical models is of great interest, especially in the rehabilitation field. Although some biomarkers and neuroimaging techniques have shown potential predictive value, there are still insufficient data to support their clinical utility in predicting poststroke functional recovery.

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Background: Cardioembolism has tendency to recur and cause lesions in distinct cerebrovascular territories. Using the imaging characteristics of cerebral lesions to determine dissemination in time and space (DTS) is a concept already used in other neurologic conditions; however, it has never been applied as a diagnostic tool in ischemic stroke etiology.

Aim: This study aimed to assess DTS as a diagnostic marker of cardioembolism.

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Introduction And Objectives: Cardioembolism is one of the most common causes of ischemic stroke, with an estimated prevalence of 20-30%, and correct diagnosis is essential given the therapeutic implications. Although stroke risk scores (CHADS2 and more recently CHA2DS2-VASc) have been validated in heterogeneous populations of patients with atrial fibrillation, their accuracy has not been ascertained for secondary stroke prevention. We set out to assess the sensitivity and specificity of the CHADS2 and CHA2DS2-VASc stroke risk scores as predictors of cardioembolic sources, documented by transesophageal echocardiography (TEE) in a population with ischemic stroke.

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