Publications by authors named "A Freese"
Herein, we demonstrate the use of lysozyme (Lys) as a model to fabricate a protein carrier system based on gold nanoparticles (AuNPs) via the Layer-by-Layer (LbL) technology. Poly(ethyleneimine) (PEI) and poly(sodium 4-styrenesulfonate) (PSS) were used as cationic and anionic polymers respectively to grow oppositely charged layers. Mild aqueous conditions were utilized to avoid protein denaturation and activity instead of organic solvents that have been used in other encapsulation systems.
View Article and Find Full Text PDFChildren with migration background are at particular risk for overweight. We assessed the effects of a primary school-based initiative targeted at enhancing physical activity and dietary education among children with a high proportion of migration background. Four 3 and 4 grade classes (n=70 children, 77% with migration background) participated in a 10-months intervention comprising 2 additional exercise lessons weekly and 10 nutrition lessons per school year.
View Article and Find Full Text PDFImportance: Liposomal bupivacaine is a novel extended-duration anesthetic that has recently been used for local infiltration in total knee arthroplasty (TKA). Athough liposomal bupivacaine is widely used, it is unknown if the benefits justify the cost in the veteran population at our institution.
Objective: To evaluate a change in practice: the effect of local infiltration of liposomal bupivacaine on perioperative outcomes in patients undergoing primary TKA.
Objective: A known HIV status is the most important step in preventing mother-to-child transmission of HIV and screening for HIV is recommended by German prenatal guidelines. In our study, we wanted to ascertain the prevalence of HIV-testing in a pregnant inner-city cohort.
Methods: Prenatal records of 279 women were prospectively studied, and the testing confirmed with the prenatal care providers.
Article Synopsis
- Canavan disease is a genetic disorder caused by mutations in the ASPA gene, leading to harmful levels of N-acetyl-aspartate in the brain and significant developmental impairments.
- A study involving 28 patients, including 13 treated with gene therapy using the AAV2-ASPA vector, aimed to evaluate the long-term safety and effectiveness of this treatment.
- Results showed no long-term adverse effects from the gene therapy, with positive changes in brain chemistry, slowed brain atrophy, reduced seizure frequency, and overall stabilization of clinical status.