Publications by authors named "A Fratta"
Article Synopsis
- * Researchers measured gamma H2AX levels and the transcription of DNA repair marker genes (NAC82, KU70, AGO2), finding no significant increase in DSBs but elevated transcription of these genes upon infection.
- * A mutation in the virB5 gene of Agrobacterium reduced the activation of DNA repair genes, suggesting that the transport of specific bacterial effectors into the plant cell is necessary for triggering the plant's DNA repair mechanisms.
Antiphospholipid syndrome (APS), also known as Hughes syndrome, is an acquired autoimmune and procoagulant condition that predisposes individuals to recurrent thrombotic events and obstetric complications. Central is the role of three types of antiphospholipid antibodies that target phospholipid-binding proteins: lupus anticoagulant (LAC), anti-β2-glycoprotein I (β2-GPI-Ab), and anti-cardiolipin (aCL). Together with clinical data, these antibodies are the diagnostic standard.
View Article and Find Full Text PDFPredictive values of relative fat mass and body mass index on cardiovascular health in community-dwelling older adults: Results from the Longevity Check-up (Lookup) 7.
Maturitas
July 2024
Objectives: To assess the predictive value of relative fat mass compared to body mass index for hypertension, diabetes, hyperlipidemia, and heightened cardiovascular risk in a cohort of community-dwelling older adults from the Longevity Check-up 7+ cohort.
Study Design: Retrospective cross-sectional study.
Main Outcome Measures: Hyperlipidemia was defined as total cholesterol ≥200 mg/dL or ongoing lipid-lowering treatment.
Congenital hydrocephalus and ventriculomegaly can be diagnosed reliably with prenatal ultrasound and Magnetic Resonance Imaging (MRI). Unilateral hydrocephalus is uncommon, and the prognosis depends on etiology and postnatal management. Here, we present a case of a 32-years-old woman with prenatal diagnosis of unilateral hydrocephalus associated with stenosis of the foramen of Monro.
View Article and Find Full Text PDFArticle Synopsis
- Acute gingivostomatitis, a common viral condition in children, is very painful and often leads to emergency department visits; this study analyzed its prevalence and pain management strategies before codeine restrictions took effect in 2013.
- Over five years at a pediatric emergency department, 702 children were studied, with a notable majority experiencing pain and feeding difficulties, particularly among those with herpetic gingivostomatitis.
- The research highlighted that 65.1% of children received codeine for pain relief, emphasizing the need for effective alternative analgesic treatments after the restriction of codeine use.