Publications by authors named "A Frantz"
A patient with a percutaneously inserted cardiopulmonary bypass cannula into the right internal jugular vein, connected to an extracorporeal membrane oxygenation (ECMO) circuit using tape, was referred for transport to our ECMO center. We describe management, quality improvement, and lessons learned.
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- * A cluster-randomised trial involved 197 employees, with results analyzed using generalized estimating equations due to skewed sickness absence data.
- * Findings showed no significant difference in sickness absence days between those receiving PSI-WPI (median 78 days) and those receiving standard care (median 64 days), suggesting additional factors in the health care system may limit effectiveness.
Local protein synthesis in axons and dendrites underpins synaptic plasticity. However, the composition of the protein synthesis machinery in distal neuronal processes and the mechanisms for its activity-driven deployment to local translation sites remain unclear. Here, we employed cryo-electron tomography, volume electron microscopy, and live-cell imaging to identify Ribosome-Associated Vesicles (RAVs) as a dynamic platform for moving ribosomes to distal processes.
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- Hemangiosarcoma in dogs and angiosarcoma in humans are aggressive sarcomas originating from blood vessel-forming cells, characterized by disorganized vascular spaces and high metastasis rates.
- The study used dog-in-mouse xenografts to mimic the tumors' properties, observing the complex interaction between donor and host cells, which led to the development of myeloid hyperplasia and lymphoproliferative tumors.
- Findings suggest that these sarcomas create a supportive microenvironment for hematopoietic (blood cell) growth, indicating a potential role in tumor progression by regulating surrounding stromal and immune responses.
Electrocatalytic Transfer Hydrogenation of 1-Octene with [(PCP)Ir(H)(Cl)] and Water.
Angew Chem Int Ed Engl
July 2024
Electrocatalytic hydrogenation of 1-octene as non-activated model substrate with neutral water as H-donor is reported, using [(PCP)Ir(H)(Cl)] (1) as the catalyst, to form octane with high faradaic efficiency (FE) of 96 % and a k of 87 s. Cyclic voltammetry with 1 revealed that two subsequent reductions trigger the elimination of Cl and afford the highly reactive anionic Ir(I) hydride complex [(PCP)Ir(H)] (2), a previously merely proposed intermediate for which we now report first experimental data by mass spectrometry. In absence of alkene, the stoichiometric electrolysis of 1 in THF with water selectively affords the Ir(III) dihydride complex [(PCP)Ir(H)] (3) in 88 % FE from the reaction of 2 with HO.
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