Proteomic profile of extracellular vesicles from plasma and CSF of multiple sclerosis patients reveals disease activity-associated EAAT2.

Background And Objectives: There is an urgent need to discover blood-based biomarkers of multiple sclerosis (MS) to better define the underlying biology of relapses and monitor disease progression. The main goal of this study is to search for candidate biomarkers of MS relapses associated with circulating extracellular vesicles (EVs), an emerging tool for biomarker discovery.

Methods: EVs, purified from unpaired plasma and CSF samples of RRMS patients by size-exclusion chromatography (SEC), underwent proteomic analysis to discover novel biomarkers associated with MS relapses.

Drivers of epidemic dynamics in real time from daily digital COVID-19 measurements.

Understanding the drivers of respiratory pathogen spread is challenging, particularly in a timely manner during an ongoing epidemic. In this work, we present insights that we obtained using daily data from the National Health Service COVID-19 app for England and Wales and that we shared with health authorities in almost real time. Our indicator of the reproduction number () was available days earlier than other estimates, with an innovative capability to decompose () into contact rates and probabilities of infection.

Replacing maize silage with hydroponic barley forage in lactating water buffalo diet: Impact on milk yield and composition, water and energy footprint, and economics.

This study investigated the feasibility of integrating hydroponic barley forage (HBF) production into dairy ruminant production, focusing on its effect on milk yield and components, energy and water footprints, and economic implications. Maize silage (MSil) was used as a benchmark for comparison. The research was conducted on a water buffalo dairy farm equipped with a fully automated hydroponic system producing approximately 6,000 kg/d of HBF as fed (up 1,000 kg/d on DM basis).

Comparing conventional and modified Seldinger techniques using a micro-insertion kit for PICC placement in neonates: a retrospective cohort study.

Objective: This study aims to assess the comparative effectiveness of a conventional splitting needle or a peelable cannula vs. the modified Seldinger technique (MST) by utilizing a dedicated micro-insertion kit across various clinically significant metrics, including insertion success, complications, and catheter-related infections.

Methods: We conducted a retrospective observational cohort study using an anonymized data set spanning 3 years (2017-2019) in a large tertiary-level neonatal intensive care unit in Qatar.

The "Hysterical Psychosis" Dilemma: A Narrative Review.

Background: Hysteria in its most severe expression may reach psychotic manifestations. Such symptomatology has been occasionally described by various authors starting from the 19th century and defined as "hysterical psychosis" (HP) by Hollender and Hirsch in 1964. Currently, diagnostic psychiatric manuals such as DSM and ICD do not include the diagnosis of HP, although this term is commonly used in clinical practice.