Publications by authors named "A Foy"

Importance: Heart failure (HF) hospitalization is a common end point in HF trials; however, how HF hospitalization is associated with all-cause hospitalization in terms of proportionality, correlation of treatment effects, and concomitant reporting has not been studied.

Objective: To determine the ratio of HF to all-cause hospitalizations, whether reported treatment effects on HF hospitalization are associated with treatment effects on all-cause hospitalization, and how often all-cause hospitalization is reported alongside HF hospitalization.

Data Sources: PubMed was searched from inception to September 2, 2024, for randomized clinical trials (RCTs) of HF treatments using MeSH (medical subject heading) terms and keywords associated with heart failure, ventricular failure, ventricular dysfunction, and cardiac failure, as well as the names of specific journals.

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Article Synopsis
  • The review emphasizes the necessity of integrating machine learning workflows into hospital settings to align with clinical practices and real-world data.
  • The paper discusses the development and implementation of a novel clinical NLP service within the UK's National Health Service, focusing on creating a framework to incorporate expert clinical insight into NLP models.
  • The project has generated over 26,000 annotations and demonstrated various clinical uses of named entity recognition, suggesting that NLP services will soon be essential in healthcare.
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Older patients with heart failure are particularly vulnerable due to a wide range of associated comorbidities, disability, and frailty. This population often receives multiple prescriptions, increasing the risk of adverse drug reactions, non-adherence, and drug interactions. Deprescribing, which involves reducing the number of medications to the lowest clinically reasonable limit, has the potential to decrease the risk of drug interactions and enhance patients' quality of life.

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Article Synopsis
  • A 52-year-old man visits his internal medicine clinic for high blood pressure management, having been diagnosed with hypertension 5 years ago, and is also dealing with obesity and high cholesterol.
  • Despite taking multiple medications, his blood pressure remains high, indicating resistant hypertension, which often comes with other health issues like obesity and sleep apnea.
  • The study discusses the evolving understanding of the causes of resistant hypertension and looks into four key areas: the sympathetic nervous system, aldosterone levels, blood vessel function, and inflammation, along with new treatments being researched.
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