Publications by authors named "A Fountas"
Objective: Central diabetes insipidus or vasopressin deficiency (AVP-D) is the most frequent water balance disorder after transsphenoidal surgery (TSS) with variable prevalence amongst studies. We aimed to determine rates of newly developed transient or permanent AVP-D in patients with pituitary tumours treated with TSS.
Design And Methods: We performed systematic review of Medline, Embase, and Cochrane Library between January 1, 2000 and January 31, 2021 for studies reporting on outcomes for pituitary adenoma, craniopharyngioma, and Rathke's cleft cyst (RCC) after TSS and providing definition of post-operative AVP-D.
Article Synopsis
- The study aims to improve the understanding of non-functioning pituitary microadenomas (micro-NFPAs) and their natural progression to inform patient care.
- Conducted across 23 endocrine departments in the UK, it analyzed clinical data from 459 patients over a median of 3.5 years, assessing tumor growth and hormonal changes.
- Results indicate a low probability of tumor growth (7.8% at 3 years) and rare development of hypopituitarism, suggesting that follow-up MRIs every 3 years and less frequent hormonal checks are adequate for managing micro-NFPAs.
Purpose: The optimal management approach for presumed non-functioning pituitary microadenomas (microNFPAs) remains unclear. Our aim was to capture current UK practice and identify changes with time.
Methods: Two online surveys investigating clinicians' approaches were performed in 2009-2010 and 2021-2022 (advertised through Society for Endocrinology UK).
Nelson's syndrome is a potentially severe condition that may develop in patients with Cushing's disease treated with bilateral adrenalectomy. Its management can be challenging. Pituitary surgery followed or not by radiotherapy offers the most optimal tumour control, whilst pituitary irradiation alone needs to be considered in cases requiring intervention and are poor surgical candidates.
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