Can we rely on magnetic resonance imaging for prostate cancer detection and surgical planning? Comprehensive analysis of a large cohort of patients undergoing transperineal mapped biopsies.

Purpose: To evaluate MRI and histological concordance in prostate cancer (PCa) identification via mapped transperineal biopsies.

Methodology: Retrospective per-lesion analysis of patients undergoing MRI and transperineal biopsy at the Valencian Institute of Oncology (2016-2024) using CAPROSIVO PCa data. Patients underwent MRI, with or without regions of interest (ROI), followed by transperineal biopsies (3-5 cores/ROI, 20-30 systematic).

Prostate cancer patients with lymphatic node involvement detected by immunohistochemistry. Is the effort worthwhile?

Introduction: Lymph node (LN) status is one of the main prognostic factors in localized prostate cancer (CaP) patients after surgery. Examining palpable lymph nodes with hematoxylin and eosin (HE) is the most common approach in clinical practice; however, immunohistochemistry (IHC) has been reported to increase the LN detection rate. We reviewed the oncological results of patients with LN metastasis detected by IHC.

Is Unilateral Lymphadenectomy an Option in Selected Patients with Prostate Cancer?

Background: Evidence regarding the relationship between the laterality of lymph node invasion (LNI) and the prostatic lobe affected is limited. Our aim was to review our records of patients with exclusively unilateral localised prostate cancer (PCa) with metastatic LN involvement.

Methods: Between 2006 and 2023, after radical prostatectomy and extended pelvic lymphadenectomy at our centre, thirty patients with intermediate-high risk unilateral PCa and pN1 disease were identified.

Deficits in geriatric assessment are important in relation to fatigue in older patients with Inflammatory Bowel Disease.

Background: No previous study has investigated fatigue in older patients with Inflammatory Bowel Disease (IBD).

Aims: To describe the prevalence of fatigue in older patients and compare it to the prevalence in younger patients with IBD, and to determine factors associated with fatigue.

Methods: A prospective, multicenter cohort study, including older- (≥ 65 years) and younger patients with IBD (18-64 years).

Enhanced Activation of Peroxymonosulfate for Tetracycline Degradation Using CoNi-Based Electrodeposited Films.

Synthesizing efficient heterogeneous catalysts with multiple active sites able to activate peroxymonosulfate (PMS) for the degradation of persistent organic pollutants continues to be a challenge for societies worldwide. In response, cost-effective, eco-friendly oxidized Ni-rich and Co-rich CoNi micro-nanostructured films were fabricated following a two-step process based on simple electrodeposition using green deep eutectic solvent as an electrochemical media and thermal annealing. The CoNi-based catalysts demonstrated exceptional efficiency in the heterogeneous catalyzed activation of PMS for tetracycline degradation and mineralization.