Publications by authors named "A Fogo"
Article Synopsis
- Traditional models of kidney injury focus mainly on either glomeruli or tubules, but new research indicates that both areas interact and contribute to chronic kidney disease.
- Damage to glomeruli can lead to tubule injury by allowing harmful substances into the tubules, which can worsen kidney function over time.
- Conversely, injury in the tubules can also harm glomeruli, highlighting a two-way relationship that is crucial for understanding kidney disease and exploring treatment options.
Glomeruli filter blood through the coordination of podocytes, mesangial cells, fenestrated endothelial cells, and the glomerular basement membrane. Cellular changes, such as podocyte loss, are associated with pathologies like diabetic kidney disease. However, little is known regarding the in situ molecular profiles of specific cell types and how these profiles change with disease.
View Article and Find Full Text PDFThe XVI-th Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from 19th-23rd September 2022, as a joint meeting with the Canadian Society of Transplantation. To mark the 30 anniversary of the first Banff Classification, pre-meeting discussions were held on the past, present, and future of the Banff Classification. This report is a summary of the meeting highlights that were most important in terms of their effect on the Classification, including discussions around microvascular inflammation and biopsy-based transcript analysis for diagnosis.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates how amyloid deposition affects kidney function in patients with amyloid light-chain (AL) amyloidosis, using data from renal biopsies in the RAIN trial to find relevant molecular signatures.
- - Researchers performed detailed transcriptional profiling and created a histologic scoring tool, identifying two distinct patient groups based on gene expression patterns and noted differences in scarring and inflammatory pathways.
- - The findings suggest that further research with larger sample sizes and advanced techniques could pinpoint specific kidney cell responses to amyloid deposits, paving the way for new treatments.
Background: Genetic variants in are associated with autosomal dominant tubulointerstitial kidney disease. SEC61A1 is a translocon in the endoplasmic reticulum membrane and variants affect biosynthesis of renin and uromodulin.
Methods: A patient is described that presented at 1 year of age with failure-to-thrive, kidney failure (glomerular filtration rate, GFR, 18 ml/min/1.